Evicenter
P&T meetings

Bezuclastinib

Nonadvanced systemic mastocytosis

Manufacturer
Cogent Biosciences
Regulatory submission
NDA submitted December 2025
62 sources

Section 5 of 6

Economic information and modeling report

2 evidence topics · 2 sources

Modeling overview

Summary

The verified economic result concerns avapritinib plus best supportive care versus best supportive care alone: the Canadian recommendation reports an ICER of $1,871,956 per QALY gained. This is comparator cost-effectiveness evidence, not a bezuclastinib budget impact estimate. No bezuclastinib-specific price or eligible budget impact model is included in the report, so comparator estimates cannot populate the product-specific model.

Canadian reimbursement recommendation: avapritinib plus BSC versus BSC alone, base-case ICER

Bezuclastinib-specific price, cost-effectiveness analysis, and budget-impact model

No evidence found.

Budget impact model

Approach and framework

Bezuclastinib-specific models

No evidence found.

Perspective and time frame

No evidence found.

Epidemiology and eligible population inputs

No evidence found.

Cost assumptions

No evidence found.

Model outcomes

No evidence found.

Results

Base case

No evidence found.

Scenario analyses

No evidence found.

Budget impact model discussion

No evidence found.