Company-reported prevalence

Cytisinicline

Overview

Field	Value
Drug	Cytisinicline
Indication	Smoking cessation
Disease	Nicotine dependence: adults who smoke combustible cigarettes, adults who use e-cigarettes, and those who want to quit or attempt to quit
Company	Achieve Life Sciences (development and commercialization rights in the United States, under an exclusive license and supply agreement with Sopharma AD); Sopharma AD (licensor; markets cytisinicline in Central and Eastern Europe)
Documents searched	Achieve Life Sciences website, home page and references page, October 2026; Achieve Life Sciences website, products page, October 2026; Achieve Life Sciences corporate presentation, July 2026; Achieve Life Sciences Form 10-K for 2025, filed March 2026; Achieve Life Sciences Form 10-K/A for 2025, 2026; Achieve Life Sciences press releases of October 7, 2026, October 6, 2026, October 1, 2026, September 28, 2026, August 2026 (second quarter 2026 results), May 19, 2026, 2026 (complete response letter), and September 3, 2025 (NDA acceptance)
Data as of	October 14, 2026
Prepared by	AI research agent (Claude); not yet reviewed by a person

Company statements of prevalence

United States

Number affected: Achieve Life Sciences press release, October 2026

“There are approximately 25 million adults in the United States who smoke combustible cigarettes.” (opens the source at this quote in a new tab)
“In addition, there are nearly 18 million adults in the United States who use e-cigarettes, also known as vaping.” (opens the source at this quote in a new tab)

Cited source: 2.1 Agaku 2026

Achieve Life Sciences (2026) press release, October 7, 2026, quoted passage highlighted — Captured from the passage on the page (opens in a new tab)

Number affected (middle and high school students using e-cigarettes): Achieve Life Sciences press release, October 2026

“In 2025, approximately 1.4 million middle and high school students in the United States reported using e-cigarettes.” (opens the source at this quote in a new tab)

Cited source: 2.2 Park-Lee 2026

Number affected: Achieve Life Sciences website, October 2026

“25M” (opens the source at this quote in a new tab)
“Smokers in the US” (opens the source at this quote in a new tab)
“18M” (opens the source at this quote in a new tab)
“E-Cigs in the US” (opens the source at this quote in a new tab)

Cited source: 2.1 Agaku 2026

Achieve Life Sciences (2026) website, home page, quoted passage highlighted — Captured from the passage on the page (opens in a new tab)

Prevalence (share of adults who smoke attempting to quit each year): Achieve Life Sciences website, October 2026

“While over half attempt to quit smoking each year,” (opens the source at this quote in a new tab)

Cited source: 2.3 VanFrank 2024

Number affected: Achieve Life Sciences corporate presentation, July 2026

“A large, underserved U.S. nicotine-dependence market” (opens the source at this quote in a new tab)
“~48M” (opens the source at this quote in a new tab)
“U.S. tobacco / nicotine users” (opens the source at this quote in a new tab)
“~38M” (opens the source at this quote in a new tab)
“Smokers and/or vapers” (opens the source at this quote in a new tab)
“25M” (opens the source at this quote in a new tab)
“Adult cigarette smokers” (opens the source at this quote in a new tab)
“~18M” (opens the source at this quote in a new tab)
“E-cigarette (vape) users” (opens the source at this quote in a new tab)

Cited source: 2.1 Agaku 2026

Achieve Life Sciences (2026) corporate presentation, July 2026, quoted passage highlighted — Captured from page 6 of 25 (opens in a new tab)

Number affected (people attempting to quit each year): Achieve Life Sciences corporate presentation, July 2026

“Most try to quit, and most fail” (opens the source at this quote in a new tab)
“~15M” (opens the source at this quote in a new tab)
“Attempt to quit each year” (opens the source at this quote in a new tab)
“~14M” (opens the source at this quote in a new tab)
“Fail to quit each year” (opens the source at this quote in a new tab)

Cited source: 2.6 Centers for Disease Control and Prevention 2026a

Prevalence (share of adults who smoke wanting to quit): Achieve Life Sciences corporate presentation, July 2026

“And most users want to quit” (opens the source at this quote in a new tab)
“~68%” (opens the source at this quote in a new tab)
“of U.S. adults who smoke want to quit” (opens the source at this quote in a new tab)

Cited source: 2.6 Centers for Disease Control and Prevention 2026a

Prevalence (share of adults who vape planning to quit): Achieve Life Sciences corporate presentation, July 2026

“~60%” (opens the source at this quote in a new tab)
“of U.S. adults who vape plan to quit” (opens the source at this quote in a new tab)

Cited source: 2.7 Centers for Disease Control and Prevention 2026b

Prevalence (share of adults aged 18 to 34 who vape): Achieve Life Sciences corporate presentation, July 2026

“~1 in 7” (opens the source at this quote in a new tab)
“U.S. adults aged 18-34 vape, with 21-24 being the highest rate of any age group (15.5%)” (opens the source at this quote in a new tab)

Cited source: 2.8 National Center for Health Statistics 2026; 2.4 Vahratian 2025

Prevalence (share of adults using e-cigarettes, 2020 and 2024): Achieve Life Sciences corporate presentation, July 2026

“Adult e-cigarette use rose from 3.7% (2020) to 7.0% (2024).” (opens the source at this quote in a new tab)

Cited source: 2.1 Agaku 2026

Number affected: Achieve Life Sciences Form 10-K for 2025, March 2026

“There are an estimated 29 million adults in the United States alone who smoke combustible cigarettes and an estimated 17 million adults in the United States who utilize e-cigarettes.” (opens the source at this quote in a new tab)

Cited source: None stated in the document.

Achieve Life Sciences (2026) Form 10-K for 2025, quoted passage highlighted — Captured from the passage on the page (opens in a new tab)

Number affected (adults who use e-cigarettes): Achieve Life Sciences Form 10-K for 2025, March 2026

“According to data from the National Health Interview Survey, published by the CDC in May 2025, it is estimated that 17 million adults in the United States used e-cigarettes in 2023.” (opens the source at this quote in a new tab)

Cited source: None stated in the document.

Prevalence (share of adults who smoke wanting to quit or attempting to quit): Achieve Life Sciences Form 10-K for 2025, March 2026

“The CDC estimates that more people in the United States are addicted to nicotine than any other drug and reports that, historically, nearly 70% of smokers desired to quit and 55% made an attempt to do so in the prior year.” (opens the source at this quote in a new tab)

Cited source: None stated in the document.

Number affected: Achieve Life Sciences press release, September 2025

“There are approximately 29 million adults in the United States who smoke combustible cigarettes.” (opens the source at this quote in a new tab)
“In addition, there are approximately 17 million adults in the United States who use e-cigarettes, also known as vaping.” (opens the source at this quote in a new tab)

Cited source: 2.3 VanFrank 2024; 2.4 Vahratian 2025

Achieve Life Sciences (2025) press release, September 3, 2025, quoted passage highlighted — Captured from the passage on the page (opens in a new tab)

Number affected (middle and high school students using e-cigarettes): Achieve Life Sciences press release, September 2025

“In 2024, approximately 1.6 million middle and high school students in the United States reported using e-cigarettes.” (opens the source at this quote in a new tab)

Cited source: 2.5 Jamal 2024

Number affected (people attempting to quit each year): Achieve Life Sciences press release, September 2025

“Each year, an estimated 15 million Americans attempt to quit smoking,” (opens the source at this quote in a new tab)

Cited source: None stated in the document.

Europe

No evidence found.

Global

Number affected (all tobacco users): Achieve Life Sciences Form 10-K for 2025, March 2026

“In 2024, the World Health Organization, or WHO, estimated that there are approximately 1.2 billion tobacco users globally” (opens the source at this quote in a new tab)

Cited source: None stated in the document.

Other countries and regions

No evidence found.

Geography not stated

Prevalence (share of e-cigarette users surveyed by the company intending to quit): Achieve Life Sciences Form 10-K for 2025, March 2026

“A study that we conducted and that was presented at the 2021 SRNT Annual Meeting, showed results from surveying approximately 500 users of nicotine vaping devices or e-cigarettes with approximately 73% of participants responding that they intend to quit vaping within the next three to 12 months.” (opens the source at this quote in a new tab)

Cited source: 2.9 Achieve Life Sciences 2021

Sources the company cites

Agaku 2026

Reference as the company lists it, press release, October 7, 2026

“Agaku I. Tobacco Product Use among U.S. Adults, 2023–2024, NEJM Evidence, doi: 10.1056/EVIDpha2500339.” (opens the source at this quote in a new tab)

Reference as the company lists it, corporate presentation, July 2026

“Agaku I. Tobacco Product Use among U.S. Adults, 2023-2024. NEJM Evidence 2026. doi:10.1056/EVIDpha2500339 (47.7M any tobacco product; 25.2M cigarette; 17.8M e-cigarette users).” (opens the source at this quote in a new tab)
“Adult e-cigarette use rose from 3.7% (2020) to 7.0% (2024). CDC; Agaku I, NEJM Evidence 2026, doi:10.1056/EVIDpha2500339.” (opens the source at this quote in a new tab)

Reference as the company lists it, website, references page

“Agaku I. Tobacco Product Use among U.S. Adults, 2023–2024, NEJM, doi: 10.1056/EVIDpha2500339;” (opens the source at this quote in a new tab)

Achieve Life Sciences (2026) website, references page, quoted passage highlighted — Captured from the passage on the page (opens in a new tab)

Passage carrying the nearest figure

“prevalence of cigarette smoking among U.S. adults declined from 10.8% of the population in 2023 to 9.9% in 2024.” (opens the source at this quote in a new tab)
“18.8% of adults (47.7 million) used at least one tobacco product.” (opens the source at this quote in a new tab)

Agaku 2026, quoted passage highlighted — Captured from the passage on the page (opens in a new tab)

Park-Lee 2026

Reference as the company lists it

“Eunice Park-Lee, Lauren M Dutra, Hannah Cowan, et al. Tobacco Product Use Among Middle and High School Students in the United States: National Youth Tobacco Survey, 2025,” (opens the source at this quote in a new tab)

Passage carrying the nearest figure

“Among high school (grades 9-12) and middle school (grades 6-8) students, an estimated 2.01 million or 7.2% reported current tobacco use, 5.2% e-cigarette use, 2.6% combusted tobacco use, and 1.7% nicotine pouch use.” (opens the source at this quote in a new tab)

Park-Lee 2026, quoted passage highlighted — Captured from the passage on the page (opens in a new tab)

VanFrank 2024

Reference as the company lists it, press release, September 3, 2025

“VanFrank B, Malarcher A, Cornelius ME, Schecter A, Jamal A, Tynan M. Adult Smoking Cessation” (opens the source at this quote in a new tab)
“United States, 2022. MMWR Morb Mortal Wkly Rep 2024;73:633–641.” (opens the source at this quote in a new tab)

Reference as the company lists it, website, references page

“VanFrank B, Malarcher A, Cornelius ME, Schecter A, Jamal A, Tynan M. Adult Smoking Cessation” (opens the source at this quote in a new tab)

Passage carrying the figure

“In 2022, approximately two thirds (67.7%) of the 28.8 million U.S. adults who smoked wanted to quit, and approximately one half (53.3%) made a quit attempt, but only 8.8% quit smoking.” (opens the source at this quote in a new tab)

VanFrank 2024, quoted passage highlighted — Captured from the passage on the page (opens in a new tab)

Vahratian 2025

Reference as the company lists it, press release, September 3, 2025

“Vahratian A, Briones EM, Jamal A, Marynak KL. Electronic cigarette use among adults in the United States, 2019–2023. NCHS Data Brief, no 524.” (opens the source at this quote in a new tab)

Reference as the company lists it, corporate presentation, July 2026

“CDC. https://www.cdc.gov/nchs/data/databriefs/db524.pdf” (opens the source at this quote in a new tab)

Passage carrying the nearest figure

“The percentage of adults who used electronic cigarettes increased from 4.5% in 2019 to 6.5% in 2023.” (opens the source at this quote in a new tab)
“In 2023, young adults ages 21-24 were most likely to use electronic cigarettes (15.5%).” (opens the source at this quote in a new tab)

Vahratian 2025, quoted passage highlighted — Captured from the passage on the page (opens in a new tab)

Jamal 2024

Reference as the company lists it

“Jamal A, Park-Lee E, Birdsey J, et al. Tobacco Product Use Among Middle and High School Students” (opens the source at this quote in a new tab)
“National Youth Tobacco Survey, United States, 2024. MMWR Morb Mortal Wkly Rep 2024;73:917–924.” (opens the source at this quote in a new tab)

Passage carrying the figure

“During 2023–2024, among all students, the estimated number who reported current use of any tobacco product decreased from 2.80 to 2.25 million students; e-cigarette use decreased (from 2.13 to 1.63 million students)” (opens the source at this quote in a new tab)

Jamal 2024, quoted passage highlighted — Captured from the passage on the page (opens in a new tab)

Centers for disease control and prevention 2026a

Reference as the company lists it

“CDC. Smoking Cessation: Fast Facts, 2022 (~53% of adults who smoke make a quit attempt annually; fewer than 1 in 10 succeed).” (opens the source at this quote in a new tab)
“CDC. Smoking Cessation: Fast Facts, 2022: 67.7% of adults who smoke reported wanting to quit.” (opens the source at this quote in a new tab)

Passage carrying the nearest figure

“In 2022, 67.7% of adults who smoked said they wanted to quit smoking.” (opens the source at this quote in a new tab)
“In 2022, 53.3% of adults who smoked said they had tried to quit in the past year.” (opens the source at this quote in a new tab)
“In 2022, 8.8% of adults who smoked were able to successfully quit smoking in the past year.” (opens the source at this quote in a new tab)

Centers for Disease Control and Prevention (2026) Smoking Cessation: Fast Facts, quoted passage highlighted — Captured from the passage on the page (opens in a new tab)

Centers for disease control and prevention 2026b

Reference as the company lists it

“CDC. E-Cigarette Use Among Adults: 60.1% of adults who currently vape reported plans to quit (2016-2018 study).” (opens the source at this quote in a new tab)

Passage carrying the figure

“In a 2016–2018 study, 60.1% of adults who currently used e-cigarettes reported having future plans to quit e-cigarettes.” (opens the source at this quote in a new tab)

Centers for Disease Control and Prevention (2026) E-Cigarette Use Among Adults, quoted passage highlighted — Captured from the passage on the page (opens in a new tab)

National center for health statistics 2026

Reference as the company lists it

“National Center for Health Statistics. Percentage of current electronic cigarette use for adults aged 18 and over, United States, 2019” (opens the source at this quote in a new tab)
“2024. National Health Interview Survey. Generated interactively: Jun 01 2026 from https://wwwn.cdc.gov/NHISDataQueryTool/SHS_adult/index.ht.” (opens the source at this quote in a new tab)

Passage carrying the figure

Not quoted: The cited source is an interactive query of the National Health Interview Survey that a person must run; it has no fixed passage to quote.

Achieve life sciences 2021

Reference as the company lists it

“A study that we conducted and that was presented at the 2021 SRNT Annual Meeting” (opens the source at this quote in a new tab)

Passage carrying the figure

Not quoted: The Form 10-K names a company survey presented at the 2021 Society for Research on Nicotine and Tobacco Annual Meeting without a title, authors, or address, and no copy of the presentation was found.

Overview

1Company statements of prevalence

Number affected: Achieve Life Sciences press release, October 2026

Number affected (middle and high school students using e-cigarettes): Achieve Life Sciences press release, October 2026

Number affected: Achieve Life Sciences website, October 2026

Prevalence (share of adults who smoke attempting to quit each year): Achieve Life Sciences website, October 2026

Number affected: Achieve Life Sciences corporate presentation, July 2026

Number affected (people attempting to quit each year): Achieve Life Sciences corporate presentation, July 2026

Prevalence (share of adults who smoke wanting to quit): Achieve Life Sciences corporate presentation, July 2026

Prevalence (share of adults who vape planning to quit): Achieve Life Sciences corporate presentation, July 2026

Prevalence (share of adults aged 18 to 34 who vape): Achieve Life Sciences corporate presentation, July 2026

Prevalence (share of adults using e-cigarettes, 2020 and 2024): Achieve Life Sciences corporate presentation, July 2026

Number affected: Achieve Life Sciences Form 10-K for 2025, March 2026

Number affected (adults who use e-cigarettes): Achieve Life Sciences Form 10-K for 2025, March 2026

Prevalence (share of adults who smoke wanting to quit or attempting to quit): Achieve Life Sciences Form 10-K for 2025, March 2026

Number affected: Achieve Life Sciences press release, September 2025

Number affected (middle and high school students using e-cigarettes): Achieve Life Sciences press release, September 2025

Number affected (people attempting to quit each year): Achieve Life Sciences press release, September 2025

Number affected (all tobacco users): Achieve Life Sciences Form 10-K for 2025, March 2026

Prevalence (share of e-cigarette users surveyed by the company intending to quit): Achieve Life Sciences Form 10-K for 2025, March 2026

2Sources the company cites

Reference as the company lists it, press release, October 7, 2026

Reference as the company lists it, corporate presentation, July 2026

Reference as the company lists it, website, references page

Passage carrying the nearest figure

Reference as the company lists it

Passage carrying the nearest figure

Reference as the company lists it, press release, September 3, 2025

Reference as the company lists it, website, references page

Passage carrying the figure

Reference as the company lists it, press release, September 3, 2025

Reference as the company lists it, corporate presentation, July 2026

Passage carrying the nearest figure

Reference as the company lists it

Passage carrying the figure

Reference as the company lists it

Passage carrying the nearest figure

Reference as the company lists it

Passage carrying the figure

Reference as the company lists it

Passage carrying the figure

Reference as the company lists it

Passage carrying the figure

3References

Company statements of prevalence

Sources the company cites

References