Product information and disease description Place of product in therapy Disease description

Diagnosis

6 evidence topics · 3 sources

Optical coherence tomography in diagnosis and management

“Optical coherence tomography is important in diagnosing and managing AMD, particularly with respect to determining the presence of subretinal and intraretinal fluid and in documenting the degree of retinal thickening.” (opens the source at this quote in a new tab)
“Newer-generation OCT modalities, including SD-OCT and swept-source (SS) OCT, are preferred technologies.” (opens the source at this quote in a new tab)

Optical coherence tomography angiography: diagnostic accuracy for macular neovascularization

“Optical coherence tomography angiography (OCTA) is a noninvasive imaging modality that provides evaluation of the retinal and choroidal vasculature; it is becoming more commonly applied in the evaluation and management of AMD, but it has not replaced other angiographic methods.” (opens the source at this quote in a new tab)
“A meta-analysis of OCTA for detection of MNV revealed a sensitivity of 0.87 and specificity of 0.97.” (opens the source at this quote in a new tab)
“Optical coherence tomography angiography may detect subclinical MNV, which needs close monitoring and not treatment.” (opens the source at this quote in a new tab)

Fluorescein angiography indications

“If MNV is suspected on the basis of new symptoms or ocular findings, fluorescein angiography should be performed and interpreted expeditiously by an individual experienced in managing patients with neovascular AMD.” (opens the source at this quote in a new tab)
“The role and indications for fluorescein angiography are evolving as continued advances in OCT occur.” (opens the source at this quote in a new tab)
“Even death from anaphylaxis has been reported (approximately 1 in 200,000 patients).” (opens the source at this quote in a new tab)

Monitoring during anti-VEGF treatment and of high-risk fellow eyes

“Initial treatment and follow-up with intravitreal anti-VEGF therapy should be at approximately 4-week intervals.” (opens the source at this quote in a new tab)
“Subsequent examinations, OCT, OCTA, and fluorescein angiography should be performed as indicated depending on the clinical findings and the judgment of the treating ophthalmologist.” (opens the source at this quote in a new tab)
“Optical coherence tomography is useful and OCTA may be useful for evaluating the status of high-risk fellow eyes.” (opens the source at this quote in a new tab)

Consensus nomenclature for imaging-based classification

“The framework of a consensus nomenclature system, a definition of AMD, and a delineation of the subtypes of neovascular AMD were developed.” (opens the source at this quote in a new tab)

Pooled accuracy of optical coherence tomography angiography against fluorescein angiography in 553 eyes

“Seven primary studies were included. The quality of the evidence was good.” (opens the source at this quote in a new tab)
“The total population included in the meta-analysis comprised 553 eyes, with a cumulative sensitivity and specificity of 85.9% (95% CI 81.9-89.3%) and 89% (95% CI 83.5-93.2%), respectively, cumulative positive and negative likelihood ratios of 8.36 and 0.15, respectively (95% CI of 3.05-22.890 and 0.09-0.24, respectively), and a cumulative diagnostic odds ratio of 67.21 (95% CI 22.58-200.05).” (opens the source at this quote in a new tab)
“The evidence obtained does not demonstrate the superiority of OCTA over FA. Its use as a support technique could improve patient flow and reduce the number of FA.” (opens the source at this quote in a new tab)