Evicenter
P&T meetings

Zeleciment rostudirsen (z-rostudirsen)

Duchenne muscular dystrophy

Also known as DYNE-251
Manufacturer
Dyne Therapeutics
Regulatory submission
BLA submitted May 2026
Last updated
78 sources

Economic information and modeling report

Modeling overview

7 evidence topics · 6 sources

Summary

The identified economic evidence includes UK Markov models of a hypothetical intervention, the Project HERCULES natural-history framework, and a Japanese registry-based model using data from 730 participants. These are general DMD modeling resources, not a z-rostudirsen budget impact model. A separate systematic review identifies heterogeneity in utilities, healthcare-resource use, and costs as a source of modeling uncertainty. Product-specific price, annual treatment cost, cost-effectiveness, and budget impact estimates are not available in the evidence reproduced here.

Anticipated annual treatment cost

No evidence found.

Product-specific cost-effectiveness estimate

No evidence found.

Z-rostudirsen-specific HTA

No evidence found.

Z-rostudirsen-specific economic model

No evidence found.

U.S. payer distribution

“~ 55% Medicaid, 40% commercial, 5% Medicare/other” (opens the source at this quote in a new tab)

Utilities, costs, and healthcare-resource use

“Future economic modeling of DMD must accommodate the inherent uncertainties due to the heterogeneity of reported utilities, HCRU and costs.” (opens the source at this quote in a new tab)

DMD model frameworks

“three Markov cohort state-transition models” (opens the source at this quote in a new tab)

“a hypothetical intervention for DMD versus standard of care in a UK setting.” (opens the source at this quote in a new tab)

Project HERCULES natural-history model

“The model includes a detailed disease pathway for DMD, including the clinically and economically important transfer state.” (opens the source at this quote in a new tab)

Project HERCULES natural-history model: published correction

“In the originally published article, many of the supplementary materials were missing from the Supplementary Information file.” (opens the source at this quote in a new tab)

Registry-based Japanese economic model

“Age-specific transition probabilities were estimated by fitting a Weibull distribution to Remudy data of 730 patients.” (opens the source at this quote in a new tab)