Zipalertinib (CLN-081)

Name: Zipalertinib (CLN-081) in EGFR exon 20 insertion-mutated non-small-cell lung cancer: Mechanism of action
Published: 2026-09-14T15:39:06-04:00

EGFR exon 20 insertion-mutated non-small-cell lung cancer

Also known as TAS6417

Manufacturer: Taiho Oncology
Regulatory submission: NDA submitted February 2026
Launch: Not announced
Last updated: September 19, 2026

Section

Product information and disease description Product description Product information Pharmacology

Mechanism of action

2 evidence topics · 3 sources

Proposed mechanism of action

“next generation, irreversible EGFR inhibitor” (opens the source at this quote in a new tab)

Covalent binding site

“where it covalently modifies C797” (opens the source at this quote in a new tab)