Product information and disease description Place of product in therapy Disease description Burden of Neovascular age-related macular degeneration

Economic impact of Neovascular age-related macular degeneration on families

8 evidence topics · 7 sources

Caregiver time and transportation to injection visits

“Patients reported an average time per visit of almost 12 hours, including preappointment preparation (16 minutes), travel (66 minutes), waiting time (37 minutes), treatment time (43 minutes), and postappointment recovery (9 hours). Patients stated that caregivers took time away from work (22%) and personal activities (28%) to provide transportation to appointments.” (opens the source at this quote in a new tab)

“Approximately two‐thirds of patients required an accompanying person for travel to/from the clinic (Droege et al., 2013; Varano et al., 2015; Muller et al., 2017).” (opens the source at this quote in a new tab)

Caregiver work absenteeism: multinational survey including United States caregivers

“Caregivers estimated they provided support for 4.2 ± 2.9 days/week and 6.0 ± 7.1 h/day on average. Nearly half of caregivers (45.6%) reported some impairment in daily activities, and more than two-thirds (70.5%) of working caregivers (n = 44) reported work absenteeism due to anti-VEGF treatment/monitoring appointments.” (opens the source at this quote in a new tab)

Caregiver burden scores and contributors

“The mean CRA score was 3.2±0.5, similar to the score reported by caregivers for atrial fibrillation who require regular hospital appointments for monitoring their thromboprophylaxis. Caregiver tasks including accompanying for hospital appointments for eye treatment and patient's visual acuity in the better eye were the biggest contributors to the caregiver burden hierarchical model explaining 18% and 11% of the variance respectively.” (opens the source at this quote in a new tab)

Caregiver costs as a share of societal costs

“Direct nonmedical costs, primarily caregiver, comprised 67.1% of Study Cohort societal ophthalmic costs, versus 21.3% ($1,302/$6,116) of Control Cohort costs (P < 0.001) and 74.1% of 20/800 to no light perception subcohort costs.” (opens the source at this quote in a new tab)

Caregiver relationships and treatment barriers

“Many caregivers were a child/grandchild (47%) or partner (23%) of the patient; only 7% were professional caregivers.” (opens the source at this quote in a new tab)
“Most patients and caregivers reported a number of obstacles in managing wAMD, including the treatment itself (35% and 39%, respectively). Sixteen percent of patients also missed a clinic visit.” (opens the source at this quote in a new tab)

“Consequences of untreated neovascular AMD include a substantial economic burden on patients, their family, and society.” (opens the source at this quote in a new tab)

Transportation to injection visits and the relationship of the accompanying person

“The majority of patients (72%, 54 of 75) were driven to their appointment by a caregiver. Their caregiver was a spouse or partner (65%, 35 of 54), an adult child or grandchild (22%, 12 of 54), a friend (7%, 4 of 54), or another person (6%, 3 of 54).” (opens the source at this quote in a new tab)
“Twenty percent (15 of 75) of patients drove themselves, while 8% (6 of 75) took a car service or public or government transportation.” (opens the source at this quote in a new tab)

Out-of-pocket transportation costs reported by participants

“Few patients experienced direct out-of-pocket transportation costs. Eighty-nine percent (67 of 75) reported that they did not pay any transportation costs for their latest clinic visit. Among those who had out-of-pocket transportation cost, 12% (8 of 67) paid for parking, 6% (4 of 67) paid tolls, and 3% (2 of 67) paid bus fare.” (opens the source at this quote in a new tab)

Age, comorbidity, and household income of surveyed participants

“The average age was 79 years (range 55–98 years) and 89% (67 of 75) of patients had a concomitant medical condition. The average income was $40 000. The majority of patients (62%, 46 of 75) reported an income of less than or equal to $50 000.” (opens the source at this quote in a new tab)