Product information and disease description Place of product in therapy Disease description Epidemiology

Incidence of Neovascular age-related macular degeneration

7 evidence topics · 4 sources

United States incidence: meta-analysis in White Americans aged 50 years or older

“Annual incidence (estimated from prevalence) of late AMD in American whites was 3.5 per 1000 aged ≥50 years (95% credible interval 2.5, 4.7 per 1000), equivalent to 293 000 new cases in American whites per year (95% credible interval 207 000, 400 000). Incidence rates approximately quadrupled per decade in age. Annual incidence GA rates were 1.9 per 1000 aged ≥50 years, NVAMD rates were 1.8 per 1000.” (opens the source at this quote in a new tab)
“Late AMD incidence was 38% higher in women vs men (95% credible interval 6%, 82%).” (opens the source at this quote in a new tab)

United States incidence: Medicare beneficiaries aged 65 years or older

“Overall, the 3-year incidence of exudative AMD is estimated to be between 9.4 per 1000 and 11.4 per 1000 Americans age 65 and older (depending on ascertainment criteria), based on those diagnosed and treated by ophthalmologists for the condition.” (opens the source at this quote in a new tab)
“Women were found to have a slightly higher incidence of AMD than men using all ascertainment criteria (P < 0.001), and white Americans were found to have a fivefold-to-sixfold higher ascertainment criteria than black Americans (P < 0.001).” (opens the source at this quote in a new tab)

Europe incidence: systematic review and meta-analysis

“In the meta-analysis of incidence, the pooled annual incidence of any late AMD was 1.4 per 1 000 individuals (95% CI 0.8 to 2.6).” (opens the source at this quote in a new tab)
“Incident late AMD is estimated to increase from 400 000 per year today to 700 000 per year in 2050.” (opens the source at this quote in a new tab)

Fellow-eye incidence in untreated unilateral disease

“Neovascular AMD developed in the fellow eye in 12.2% of patients by 12 months and in 26.8% by 4 years.” (opens the source at this quote in a new tab)

United States annual incident cases by subtype, age, and sex

“This corresponds to approximately 293 000 new cases of late AMD each year (95% credible interval 207 000, 400 000), and 160 000 (95% credible interval 107 000, 234 000) and 148 000 (95% credible interval 103 000, 207 000) for GA and NVAMD, respectively.” (opens the source at this quote in a new tab)
“In those aged 65 years and older the annual incidence rate for late AMD is 7.8 per 1000 (95% credible interval 5.5, 10.6), 4.3 per 1000 for GA (95% credible interval 2.9, 6.2), and 3.9 per 1000 for NVAMD (95% credible interval 2.7, 5.5). In those aged 80 years and older the annual incidence rates per 1000 are 19.4 (95% credible interval 13.8, 26.2), 10.9 (95% credible interval 7.2, 16.1), and 9.9 (95% credible interval 6.8, 14.0), respectively.” (opens the source at this quote in a new tab)
“In those aged 65 years and older the incidence rates of NVAMD within each 5-year age group are higher in women than in men.” (opens the source at this quote in a new tab)

Share of incident cases expected to be eligible for and able to receive treatment

“Although our overall estimates of NVAMD incidence are high (owing to the inclusion of those at older ages, especially in women), this does not reflect the number in need of treatment.” (opens the source at this quote in a new tab)
“Of note, the inclusion of older ages in our estimates may include a large number who are unwilling or too frail to undergo treatment.” (opens the source at this quote in a new tab)
“Approximately 89% of the US population aged 80 years and older is white.” (opens the source at this quote in a new tab)

Sensitivity of the fellow-eye incidence estimate to outlier studies

“These cumulative incidence rates were influenced by significant heterogeneity in the studies caused by outliers.” (opens the source at this quote in a new tab)
“If outliers were not included in the analysis, the 12-month incidence rate changed considerably, from 12.2% to 8.1% (95% CI, 4.9–11.9).” (opens the source at this quote in a new tab)