Name: Azetukalner (XEN1101) in Focal onset seizures: Care management intervention strategies
Published: 2026-09-21T21:41:53-04:00

Product information and disease description Place of product in therapy Approaches to treatment

Care management intervention strategies

4 evidence topics · 4 sources

Adherence to antiseizure medications and interventions to improve it

“Poor adherence to antiepileptic medication is associated with increased mortality, morbidity and healthcare costs.” (opens the source at this quote in a new tab)
“We included 20 studies reporting data on 2832 participants.” (opens the source at this quote in a new tab)
“Behavioural interventions such as intensive reminders and the use of mixed interventions demonstrate some positive results, however, we need more reliable evidence on their efficacy, derived from carefully-designed RCTs before we can draw a firm conclusion.” (opens the source at this quote in a new tab)

Consequences of nonadherence to antiseizure medications

“Nonadherence was associated with an over threefold increased risk of mortality compared to adherence (hazard ratio = 3.32, 95% CI = 3.11-3.54) after multivariate adjustments.” (opens the source at this quote in a new tab)
“Time periods of nonadherence were also associated with a significantly higher incidence of ED visits (IRR = 1.50, 95% CI = 1.49-1.52), hospital admissions (IRR = 1.86, 95% CI = 1.84-1.88), MVA injuries (IRR = 2.08, 95% CI = 1.81-2.39), and fractures (IRR = 1.21, 95% CI = 1.18-1.23) than periods of adherence.” (opens the source at this quote in a new tab)
“These findings suggest that nonadherence to antiepileptic drugs can have serious or fatal consequences for patients with epilepsy.” (opens the source at this quote in a new tab)

Service models: specialist epilepsy nurses and self-management education

“Two intervention types, the specialist epilepsy nurse and self management education, have some evidence of benefit.” (opens the source at this quote in a new tab)
“At present it is not possible to advocate any single model of service provision.” (opens the source at this quote in a new tab)

Recommendations for specialized epilepsy centers

“The panel reached consensus on 52 recommendations covering services provided by specialized epilepsy centers in both the inpatient and outpatient settings” (opens the source at this quote in a new tab)
“All epilepsy centers should regularly screen patients for drug-resistant epilepsy and refer such patients to multidisciplinary surgical conference for consideration of epilepsy surgery.” (opens the source at this quote in a new tab)
“Telemedicine is an important resource, providing earlier access to specialized care and improving patient satisfaction, especially in resource-limited areas.” (opens the source at this quote in a new tab)