Evicenter
P&T meetings

Bezuclastinib

Nonadvanced systemic mastocytosis

Manufacturer
Cogent Biosciences
Regulatory submission
NDA submitted December 2025
Last updated
62 sources

Economic information and modeling report

Modeling overview

2 evidence topics · 2 sources

Summary

The verified economic result concerns avapritinib plus best supportive care versus best supportive care alone: the Canadian recommendation reports an ICER of $1,871,956 per QALY gained. This is comparator cost-effectiveness evidence, not a bezuclastinib budget impact estimate. No bezuclastinib-specific price or eligible budget impact model is included in the report, so comparator estimates cannot populate the product-specific model.

Canadian reimbursement recommendation: avapritinib plus BSC versus BSC alone, base-case ICER

Bezuclastinib-specific price, cost-effectiveness analysis, and budget-impact model

No evidence found.