Name: BIM-IOL System in Open-angle glaucoma or ocular hypertension: Mechanism of action
Published: 2026-09-17T18:17:42-04:00

Product information and disease description Product description Product information Pharmacology

Mechanism of action

3 evidence topics · 2 sources

Bimatoprost mechanism of action: Lumigan labeling

“Bimatoprost, a prostaglandin analog, is a synthetic structural analog of prostaglandin with ocular hypotensive activity. It selectively mimics the effects of naturally occurring substances, prostamides. Bimatoprost is believed to lower intraocular pressure (IOP) in humans by increasing outflow of aqueous humor through both the trabecular meshwork and uveoscleral routes.” (opens the source at this quote in a new tab)

Delivery mechanism: diffusion from capsular-bag pads into the aqueous humor

“Once the Drug-Pad IOL System is positioned in the capsular bag, the drug pads remain outside the visual axis and deliver the integrated medicine by” (opens the source at this quote in a new tab)
“diffusion directly into the aqueous humor, which carries the drug to the targeted tissues.” (opens the source at this quote in a new tab)

Rationale for intraocular delivery: sponsor statement on topical penetration

“Even when patients describe taking their glaucoma drops as prescribed, studies have shown that less than 5% of the administered dose penetrates the eye and reaches the target tissue.” (opens the source at this quote in a new tab)