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Dersimelagon (MT-7117)

Erythropoietic protoporphyria or X-linked protoporphyria

Manufacturer
LEO Pharma
Regulatory submission
NDA submitted June 2026
Last updated
100 sources

Product information and disease descriptionPlace of product in therapyApproaches to treatmentCurrent treatment options and standard of care

Sunlight avoidance and photoprotective measures

3 evidence topics · 3 sources

Guideline recommendation for avoidance, clothing, and tinted sunscreens

“Sunlight avoidance and opaque clothing are recommended for the prevention of phototoxic symptoms in protoporphyria ( Table 2” (opens the source at this quote in a new tab)

“Window tinting for cars can be useful” (opens the source at this quote in a new tab)

“Because some patients report a small benefit with broad-spectrum and/or tinted sunscreens such as zinc oxide and titanium dioxide and because these agents block a portion of the far UVA wavelengths (350–399 nm) of light that activate protoporphyrin, it is reasonable for patients to use these agents for the prevention of phototoxic symptoms” (opens the source at this quote in a new tab)

“However, non-broad-spectrum or non-tinted sunscreens are not useful for prevention of phototoxic symptoms in protoporphyria” (opens the source at this quote in a new tab)

“Depending on symptom severity, workplace/school accommodations and educating teachers about protoporphyria can be useful, as well as educating children regarding how to explain their disease and to advocate for themselves” (opens the source at this quote in a new tab)

Behavioral adaptation as the default in the absence of treatment

“Without access to specific treatment options that prevent or treat phototoxic reactions, patients can only adapt their behaviour by avoiding activities outdoors in sunlight and by using light filters and photo-protective clothing consisting of opaque clothing with long sleeves, headwear, gloves, enclosed footwear and shields, even during the winter months. Given the early onset of the protoporphyrias and the diagnostic delay, most patients are already conditioned to avoid (sun)light before their diagnosis.” (opens the source at this quote in a new tab)

Advice recorded in a United States medical-record cohort

“Patients were advised to use sunscreen (85%) or modify their lifestyle (83%).” (opens the source at this quote in a new tab)