Product information and disease description Place of product in therapy Disease description Epidemiology

Incidence of Schizophrenia

10 evidence topics · 11 sources

Global incidence: Global Burden of Disease Study 2021

“In 2021, approximately 1.2 million individuals worldwide (~0.015% of the global population) experienced an incident episode of schizophrenia (95% UI: 1 008 000-1 473 000). The age-standardized incidence rate for schizophrenia worldwide was 15.4 per 100 000 individuals (95% UI = 12.7-18.6), and the crude was 15.5 per 100 000 individuals (95% UI = 12.8-18.7).” (opens the source at this quote in a new tab)
“When examining age-specific crude incidence rates, rates were numerically higher for men than women for all age ranges, and incidence rates were highest among individuals ages 20-24 years for both sexes as opposed to all other age ranges” (opens the source at this quote in a new tab)
“For example, age-standardized incidence rates decreased by 4.2% in High-Income North America between 1990 and 2021 (95% UI = −5.8% to −2.6%) and increased in Eastern Europe by 5.0% (95% UI = 3.4%-6.5%) with no statistically significant change in other regions.” (opens the source at this quote in a new tab)

Global incidence: Global Burden of Disease Study 2019

“From 1990 to 2019, schizophrenia raw prevalence (14.2 to 23.6 million), incidence (941,000 to 1.3 million), and DALYs (9.1 to 15.1 million) increased by over 65%, 37%, and 65% respectively, while age-standardized estimates remained stable globally.” (opens the source at this quote in a new tab)

Global incidence: systematic review and meta-analysis, 2002 to 2017

“From 56 721 records identified, 177 met inclusion criteria. The pooled incidence of all psychotic disorders was 26·6 per 100 000 person-years (95% CI 22·0–31·7).” (opens the source at this quote in a new tab)
“The incidence of schizophrenia was available from 36 incidences from 26 citations and varied from 2·7 per 100 000 person-years (1·4–5·3) in Cavan-Monaghan (Ireland)” (opens the source at this quote in a new tab)
“Pooled incidence was lower in first contact studies (13·1 per 100 000 person-years [9·0–15·0]) than in population registers (32·8 [23·2–46·5]; figure 4).” (opens the source at this quote in a new tab)

Global incidence: systematic review of 1,458 rates from 33 countries

“Based on discrete core data for persons (55 studies and 170 rates), the distribution of rates was asymmetric and had a median value (10%–90% quantile) of 15.2 (7.7–43.0) per 100,000. The distribution of rates was significantly higher in males compared to females; the male/female rate ratio median (10%–90% quantile) was 1.40 (0.9–2.4).” (opens the source at this quote in a new tab)

United States incidence: commercial insurance and New York State Medicaid claims, 2019

“In this study incidence of schizophrenia was examined only in the 10 year continuously insured cohort, and was defined as the individuals with a diagnosis of schizophrenia in 2019 who had no prior diagnosis of schizophrenia in the preceding 10 years (1/1/2009-12/31/2018).” (opens the source at this quote in a new tab)
“Incidence was higher in Medicaid (0.19%, 95% CI: 0.18–0.20; n = 1,489 newly diagnosed in 2019); than in MarketScan (0.07%, 95% CI: 0.07–0.08; n = 712), and for males than females (Medicaid: 0.21%, 95% CI: 0.20–0.23 vs. 0.18%, 95% CI: 0.16–0.19; MarketScan: 0.08%, 95% CI: 0.07–0.09 vs. 0.07%, 95% CI: 0.07–0.08).” (opens the source at this quote in a new tab)

United States incidence: Medicaid beneficiaries in six states, 2012 to 2017

“Annual prevalence of schizophrenia ranged between 2.30% and 2.71% and annual incidence between 0.31% and 0.39% during 2012-2016.” (opens the source at this quote in a new tab)

United States incidence: weighted national claims estimate, 2022

“Researchers identified a total 653,666 patients with schizophrenia in 2022. Among them, 97,565 patients had incident schizophrenia.” (opens the source at this quote in a new tab)
“After weighting, the national prevalence of schizophrenia was estimated at 0.45% and the national incidence of schizophrenia was estimated at 0.08%” (opens the source at this quote in a new tab)

United States incidence of first-episode psychosis: five health care systems, 2007 to 2013

“Estimated true incidence rates were 86 per 100,000 per year among those aged 15 to 29 and 46 per 100,000 in those aged 30 to 59.” (opens the source at this quote in a new tab)

Incidence by sex

“The incidence risk ratios for men to develop schizophrenia relative to women were 1.42 (95% confidence interval [CI], 1.30-1.56) when all studies were included in the analysis (49 effect sizes), 1.31 (95% CI, 1.13-1.51) when studies that minimized selection biases were analyzed separately (23 effect sizes), and 1.39 (95% CI, 1.15-1.68) when only high-quality studies were included (11 effect sizes).” (opens the source at this quote in a new tab)

Age at onset

“Schizophrenia is typically diagnosed in the late teens years to early thirties, and tends to emerge earlier in males (late adolescence – early twenties) than females (early twenties – early thirties).” (opens the source at this quote in a new tab)

“Co-primary outcomes were the proportion of individuals with onset of mental disorders before age 14, 18, 25, and peak age at onset, for any mental disorder and across International Classification of Diseases 11 diagnostic blocks.” (opens the source at this quote in a new tab)
“schizophrenia-spectrum disorders/primary psychotic states: 3%, 12.3%, 47.8%, 20.5 years (k = 36, median = 25, IQR = 20–34)” (opens the source at this quote in a new tab)