Lonvoguran ziclumeran (lonvo-z)

Name: Lonvoguran ziclumeran (lonvo-z) in Hereditary angioedema: Clinical presentation - signs and symptoms
Published: 2026-09-14T15:39:06-04:00

Hereditary angioedema

Also known as NTLA-2002

Manufacturer: Intellia Therapeutics
Regulatory submission: Rolling BLA initiated April 2026 and accepted September 2026
Launch: Anticipated in the first half of 2027
Last updated: September 19, 2026

Section

Product information and disease description Place of product in therapy Disease description

Clinical presentation - signs and symptoms

3 evidence topics · 2 sources

Cutaneous swelling: hands, feet, and face

“HAE is a very rare and potentially life-threatening genetic condition involving swelling of various parts of the body, hands, feet, or face.” (opens the source at this quote in a new tab)

Gastrointestinal symptoms: intestinal attacks

“severe abdominal pain, nausea, and vomiting.” (opens the source at this quote in a new tab)

Airway symptoms: obstruction risk

“can restrict breathing and lead to life-threatening obstruction of the airway.” (opens the source at this quote in a new tab)