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SKY-0515

Huntington's disease

Last updated
211 sources

Product information and disease descriptionPlace of product in therapyDisease descriptionEpidemiology

Incidence of Huntington's disease

5 evidence topics · 6 sources

Global incidence: updated systematic review and meta-analysis, 2010 to 2022

“A total of 33 studies published between 2010 and 2022 were included. Pooled incidence was 0.48 cases per 100,000 person-years (95% CI, 0.33-0.63). Subgroup analysis by continent demonstrated a significantly higher incidence of HD in Europe and North America than in Asia.” (opens the source at this quote in a new tab)

Global incidence: systematic review and meta-analysis, 1985 to 2010

“Meta-analysis of data from four incidence studies revealed an incidence of 0.38 per 100,000 per year (95% confidence interval [CI]: 0.16, 0.94). Lower incidence was reported in the Asian studies (n = 2), compared to the studies performed in Europe, North America, and Australia (n = 6).” (opens the source at this quote in a new tab)

United States incidence: commercial insurance claims, 2003 to 2016

“Using an insurance database of over 67 million enrollees, we retrospectively identified a cohort of 3,707 individuals diagnosed with Huntington’s disease between 2003–2016.” (opens the source at this quote in a new tab)

“We estimated a cumulative age-adjusted HD frequency rate of 6.52 per 100,000 persons and a cumulative incidence rate of 1.22 per 100,000 person years.” (opens the source at this quote in a new tab)

United States incidence: Medicare beneficiaries aged 65 years or older

“In the Medicare population, 1,941 prevalent and 819 incident cases of HD were identified in 2017, corresponding to a prevalence proportion of 13.1 per 100,000 persons and incidence rate of 6.1 per 100,000 person-years.” (opens the source at this quote in a new tab)

United Kingdom incidence: primary care records

“The data showed that the incidence of HD has remained constant between 1990 and 2010 with an overall rate of 7.2 (95% CI 6.5 to 7.9) per million person-years. The systematic review identified 14 independent estimates of incidence with substantial heterogeneity and consistently lower rates reported in studies from East Asia compared with those from Australia, North America and some--though not all--those from Europe.” (opens the source at this quote in a new tab)

“There were 586 incident cases of HD from a total at‐risk population of 10,756,901 persons (corresponding to 80,048,926 PY) during the study period (Table 1). There was no evidence that incidence increased over time (β = 0.004, p = 0.4), with 16–44 newly diagnosed cases per year identified. In 2018, incidence of HD was 0.8 (0.5–1.19) per 100,000 PY.” (opens the source at this quote in a new tab)