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Tovecimig (CTX-009)

Second-line advanced biliary tract cancer

Also known as ABL001
Last updated
89 sources

Product information and disease descriptionPlace of product in therapyApproaches to treatmentCurrent treatment options and standard of care

Locoregional therapy

3 evidence topics · 2 sources

Guideline recommendations for ablation, stereotactic radiotherapy, and intra-arterial therapy

“Local ablation could be considered as an option for patients with iCCA ≤3 cm who have contraindications or are otherwise unfit for surgery [III, B]” (opens the source at this quote in a new tab)

“SBRT can be considered for patients with iCCA in case of contraindication to surgery for liver-limited disease in the palliative setting [III, C]” (opens the source at this quote in a new tab)

“Intraarterial therapies, in combination with systemic ChT, can be an option for patients with liver-limited iCCA and discussed by the MDTB according to local availability [III, C]” (opens the source at this quote in a new tab)

Hepatic artery infusion pump chemotherapy: pooled analysis of four phase 2 trials

“Systemic therapy is the standard of care for unresectable intrahepatic cholangiocarcinoma (iCCA), but overall survival (OS) remains poor.” (opens the source at this quote in a new tab)

“The pooled median OS was 26 months (95% CI 22-30), with 3-year and 5-year OS rates of 28% (95% CI 22-37) and 15% (95% CI 10-23), respectively.” (opens the source at this quote in a new tab)

“Hepatic artery infusion pump (HAIP) chemotherapy with floxuridine (FUDR) has been shown to prolong survival but is limited to expert centers.” (opens the source at this quote in a new tab)

“Liver-confined disease was defined as absence of extrahepatic metastatic disease, although locoregional lymph node metastases were allowed in the two most recent trials.” (opens the source at this quote in a new tab)

Hepatic artery infusion pump chemotherapy: pump implantation complications and biliary sclerosis

“Twenty patients (14%) had major postoperative complications following pump implantation requiring reintervention. Three patients (2%) developed ascites, which was treated with percutaneous drainage.” (opens the source at this quote in a new tab)

“Biliary sclerosis, a long-term complication associated with HAIP chemotherapy with FUDR, necessitated biliary stenting in two patients (1.4%).” (opens the source at this quote in a new tab)