Name: Tovorafenib (DAY101) in RAF-altered pediatric low-grade glioma requiring first-line systemic therapy: Administration
Published: 2026-09-17T18:16:08-04:00

Schedule, food, missed doses, and vomiting

“Take OJEMDA at a regularly scheduled time once weekly.” (opens the source at this quote in a new tab)
“OJEMDA may be taken with or without food” (opens the source at this quote in a new tab)
“3 days or less, take the missed dose as soon as possible, and take the next dose on its regularly scheduled day.” (opens the source at this quote in a new tab)
“more than 3 days, skip the missed dose and take the next dose on its regularly scheduled day.” (opens the source at this quote in a new tab)
“If vomiting occurs immediately after taking a dose, repeat that dose.” (opens the source at this quote in a new tab)

Minimum interval between doses: EU product information

“A minimum of 4 days should occur between doses.” (opens the source at this quote in a new tab)

Tablets

“Swallow tablets whole with water.” (opens the source at this quote in a new tab)
“Do not chew, cut, or crush.” (opens the source at this quote in a new tab)
“Dispense product in the original package. Tablets should not be removed from blister cards until immediately before use.” (opens the source at this quote in a new tab)

Oral suspension: reconstitution, feeding tube use, and time limit

“Reconstitute the powder in each supplied bottle with exactly 14 mL of room temperature water to form the OJEMDA for oral suspension. After reconstitution each mL contains 25 mg of tovorafenib. Product foaming after reconstitution reduces the deliverable volume.” (opens the source at this quote in a new tab)
“Each bottle delivers 300 mg of tovorafenib in 12 mL. For doses greater than 300 mg, reconstitute two bottles to achieve the dose.” (opens the source at this quote in a new tab)
“Administer OJEMDA for oral suspension using the supplied oral dosing syringe or feeding tube (minimum 12 French) immediately after preparation.” (opens the source at this quote in a new tab)
“If the OJEMDA for oral suspension is not administered within 15 minutes after preparation, instruct the patient to discard it.” (opens the source at this quote in a new tab)

Formulation interchangeability and supervision: EU product information

“The film-coated tablets and powder for oral suspension may be used interchangeably (see tovorafenib powder for oral suspension SmPC). For patients who are not able to swallow or with BSA less than 0.9 m2 the oral suspension should be provided” (opens the source at this quote in a new tab)
“Ojemda should be administered to paediatric patients under adult supervision.” (opens the source at this quote in a new tab)

First-line pLGG: formulation use in FIREFLY-2

“in the form of a tablet or liquid suspension, QW, continuously on days 1, 8, 15, and 22 of 28-day (four week) cycles.” (opens the source at this quote in a new tab)
“patients randomized to tovorafenib will receive an oral drug that is taken at home once weekly, that is available in both tablet and a pediatric friendly oral suspension that can be also given via a nasogastric or gastric tube, allowing continuation of daily activities such as attending school.” (opens the source at this quote in a new tab)