Ulixacaltamide

Name: Ulixacaltamide in Essential tremor: Mechanism of action
Published: 2026-09-14T15:39:06-04:00

Essential tremor

Manufacturer: Praxis Precision Medicines
Regulatory submission: NDA submitted by February 2026
Launch: Not announced
Last updated: September 19, 2026

Section

Product information and disease description Product description Product information Pharmacology

Mechanism of action

2 evidence topics · 4 sources

Proposed mechanism of action

“designed to block abnormal neuronal burst firing in the Cerebello-Thalamo-Cortical (CTC) circuit correlated with tremor activity.” (opens the source at this quote in a new tab)

Structural pharmacology of Z944 and Cav3.1

“The arch-shaped Z944 molecule reclines in the central cavity of the pore domain” (opens the source at this quote in a new tab)