Evicenter
P&T meetings

Zanzalintinib (XL092)

Metastatic colorectal cancer

Manufacturer
Exelixis
Regulatory submission
NDA submitted December 2025
Launch
Not announced
Last updated
65 sources

Executive summary

Burden of Metastatic colorectal cancer

1 evidence topic · 3 sources

Summary

SEER reports that 23% of colorectal cancers are diagnosed at a distant stage, with five-year relative survival of 16.9%. The American Cancer Society estimates 158,850 new colorectal cancer cases in the United States in 2026 across all stages. In a metastatic colorectal cancer cohort, the 12-month cumulative incidence of major financial hardship was 71.3%, despite 98.0% of participants having insurance.