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Zeleciment rostudirsen (z-rostudirsen)

Duchenne muscular dystrophy

Also known as DYNE-251
Manufacturer
Dyne Therapeutics
Regulatory submission
BLA submitted May 2026
Last updated
78 sources

Product information and disease descriptionPlace of product in therapyApproaches to treatment

Place in treatment, anticipated use, and care setting

1 evidence topic · 3 sources

Summary

Zeleciment rostudirsen is being developed for individuals with DMD mutations amenable to exon 51 skipping. The proposed regimen is 20 mg/kg intravenously every four weeks, with doses expressed as the PMO component. DELIVER required stable background glucocorticoids for at least 12 weeks. The reported commercial launch remains conditional on approval; final commercial distribution and administration-site requirements are not established in this report.