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Atebrioz (zilurgisertib)

Fibrodysplasia ossificans progressiva

Also known as INCB000928
Regulatory submission
NDA submitted by May 2026
Last updated
96 sources

Product information and disease descriptionPlace of product in therapyDisease descriptionBurden of Fibrodysplasia ossificans progressiva

Economic impact of Fibrodysplasia ossificans progressiva on families

5 evidence topics · 3 sources

Caregiver time, burden, and career effects

“Family members spent eight hours per day (mean) helping to provide care or assistance to their relative with FOP (Supplementary Table S7).” (opens the source at this quote in a new tab)

“Close to half (45.1%) of primary caregivers (n = 153) reported a ZBI total score between 21 and 40, indicating a mild to moderate impact on their health and/or psychological wellbeing (Supplementary Table S6).” (opens the source at this quote in a new tab)

“Over one-third of family members (38.9%) and over half of primary caregivers (51.3%) reported needing to adapt their career to look after their relative with FOP.” (opens the source at this quote in a new tab)

“When asked whether FOP had impacted career decisions, 82.8% of patients aged ≥18 years (n = 142) reported ‘yes.’” (opens the source at this quote in a new tab)

Work days missed by primary caregivers

“Primary caregivers reported missing a mean (SD) of 30.6 (87.8) days of work in the 12 months prior to completing the survey due to caring for a family member with PRMA total scores in Level 1. Mean (SD) number of work days missed was similar if the related patient had PRMA total scores in Level 3 (35.4 [91.4]) and lower for Level 2 (7.1 [13.0]) and Level 4 (3.1 [6.2]).” (opens the source at this quote in a new tab)

Emotional impact on family members

“Learning of their relative’s FOP diagnosis was very/extremely difficult for 79.2% of family members, and 85.4% of family members reported that the occurrence of flare-ups in their relative with FOP was very/extremely stressful (Supplementary Table S7).” (opens the source at this quote in a new tab)

Caregiver productivity loss in children and adolescents in China

“For patients aged < 8 years and 8–15 years, the main cost components arose from productivity loss in indirect costs incurred by caregivers totaling $7,409 ± 6,406 (52.4%) and $6,806 ± 8,367 (79.5%), respectively.” (opens the source at this quote in a new tab)

“In patients aged < 8 and 8–15 years, 50% and 23.5% were suspended or absent from school respectively. Additionally, 40.6% of those aged ≥ 16 years were unemployed due to FOP.” (opens the source at this quote in a new tab)

“Moreover, a substantial 95.5% of patients relied on caregivers for caregiving.” (opens the source at this quote in a new tab)

School accommodations for children

“Children with disabilities may be entitled to Individual Educational Programs (IEPs) to help students succeed in school. Use school aides to protect and assist children.” (opens the source at this quote in a new tab)