Evicenter
P&T meetings

Atebrioz (zilurgisertib)

Fibrodysplasia ossificans progressiva

Also known as INCB000928
Regulatory submission
NDA submitted by May 2026
Last updated
96 sources

Product information and disease descriptionProduct descriptionProduct informationDrug/Drug, drug/disease interactions

Effects of zilurgisertib on other drugs

3 evidence topics · 1 source

MATE1 and MATE2-K substrates

“Avoid concomitant use of ATEBRIOZ with MATE1 and MATE2-K substrates (e.g., metformin). If unavoidable, monitor for adverse reactions and consider dose reduction of the substrates if appropriate, according to their approved prescribing information.” (opens the prescribing information at this quote)

“ATEBRIOZ is a MATE1 and MATE2-K inhibitor. ATEBRIOZ may increase exposure of substrates of MATE1 and MATE2-K, which may increase the risk of adverse events of MATE1 and MATE2-K substrates.” (opens the prescribing information at this quote)

Cytochrome P450 inhibition and induction in vitro

“Zilurgisertib does not inhibit CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2E1, CYP3A4, or CYP2D6 at clinically relevant concentrations. Zilurgisertib is not an inducer of CYP1A2, CYP2B6, or CYP3A4.” (opens the prescribing information at this quote)

Other transporter inhibition in vitro

“Zilurgisertib is an inhibitor of MATE1 and MATE2-K and an inhibitor of OATP1B1, OATP1B3 and OCT2. Zilurgisertib is not an inhibitor of OAT1 or OAT3.” (opens the prescribing information at this quote)