Name: Atebrioz (zilurgisertib) in Fibrodysplasia ossificans progressiva: Injury prevention and supportive care
Published: 2026-09-27T12:28:00-04:00

Product information and disease description Place of product in therapy Approaches to treatment Current treatment options and standard of care

Injury prevention and supportive care

5 evidence topics · 1 source

Focus of present management

“However, present management is focused on early diagnosis, assiduous avoidance of injury and iatrogenic harm, symptomatic amelioration of painful flare-ups, optimization of residual function, and monitoring and treating co-morbidities.” (opens the source at this quote in a new tab)

Avoidance of flare-up triggers, biopsies, and elective surgery

“The prevention of flare-ups and heterotopic bone formation involves multimodal approaches. This includes the recognition and avoidance of known causes of flare-ups: contact sports, soft tissue injuries, blunt muscle trauma, muscle fatigue, muscle stretching, IM injections and immunizations, biopsies, removal of heterotopic bone, all non-emergent surgical procedures, and viral illnesses.” (opens the source at this quote in a new tab)
“If FOP is suspected, all elective procedures such as surgeries, biopsies, and IM immunizations should be deferred until a definitive diagnosis is confirmed.” (opens the source at this quote in a new tab)
“Avoid surgery, except in emergencies. Always avoid surgery to remove heterotopic bone.” (opens the source at this quote in a new tab)

Immunization route and venous access

“Immunization by subcutaneous administration is recommended for all vaccines that can be administered by that route. Avoid all IM immunizations and intranasal influenza immunizations with live vaccines as they may precipitate flare-ups of FOP.” (opens the source at this quote in a new tab)
“Central lines, PICC lines, and arterial punctures may cause HO and should be avoided unless critical for the patient’s medical management.” (opens the source at this quote in a new tab)

Anesthesia precautions

“An expert anesthesiologist experienced in general anesthesia for FOP patients must be consulted pre-operatively in all cases. If general anesthesia is required, an awake intubation by nasotracheal fiber-optic technique should be performed because of cervical spine fusions, jaw motion limitations, sensitive airway, and risk of inducing an obstructing neck flare-up.” (opens the source at this quote in a new tab)

Physical and occupational therapy and assistive care

“Passive range of motion to restore or improve joint range of motion is strictly prohibited. An assessment of ambulatory aids may be indicated. Warm water hydrotherapy may be helpful.” (opens the source at this quote in a new tab)
“Perform periodic OT evaluations for assistive devices, as activities of daily living are likely to change over time.” (opens the source at this quote in a new tab)
“Singing, swimming, and incentive spirometry are strongly encouraged to maintain lung function.” (opens the source at this quote in a new tab)