Evicenter
P&T meetings

Duravyu (vorolanib intravitreal insert)

Wet age-related macular degeneration

Also known as EYP-1901
Manufacturer
EyePoint
Launch
Not announced
Last updated
136 sources

Product information and disease descriptionPlace of product in therapyDisease description

Clinical presentation - signs and symptoms

10 evidence topics · 9 sources

Visual symptoms: metamorphopsia, central blur, and scotomas

“In late AMD (wet or dry type), many people notice that straight lines start to look wavy or crooked. You may also notice a blurry area near the center of your vision. Over time, this blurry area may get bigger or you may see blank spots. Colors may also seem less bright than before, and you may have more trouble seeing in low lighting.” (opens the source at this quote in a new tab)

“Straight lines looking wavy is a warning sign for late AMD.” (opens the source at this quote in a new tab)

Visual symptoms: guideline symptom history

“Metamorphopsia” (opens the source at this quote in a new tab)

“Decreased vision” (opens the source at this quote in a new tab)

“Scotoma” (opens the source at this quote in a new tab)

“Photopsia” (opens the source at this quote in a new tab)

“Difficulties in dark adaptation” (opens the source at this quote in a new tab)

Psychiatric symptoms: depressive symptoms at presentation for anti-VEGF therapy

“In a clinic-based cohort of 547 patients with nAMD who presented for treatment” (opens the source at this quote in a new tab)

“The prevalence of depressive symptoms was 42.04% and 31.78% as per the CES-D-10 and MHI scales, respectively.” (opens the source at this quote in a new tab)

Psychiatric symptoms: depression and Charles Bonnet syndrome in guideline counseling

“Depression and visual hallucinations (Charles Bonnet syndrome) frequently accompany severe central vision loss. Patients who have Charles Bonnet syndrome and their family members should be informed that visual symptoms are not unusual and do not represent a sign of psychosis or mental deterioration.” (opens the source at this quote in a new tab)

Visual hallucinations: Charles Bonnet syndrome prevalence meta-analysis

“We identified 18 studies with data on >4303 patients with AMD. We found an overall prevalence of CBS of 15.8% (95% confidence interval: 11.0%-21.2%). When looking at consecutively recruited patients with neovascular AMD from the clinic, prevalence of CBS was 7.2% (95% confidence interval: 4.3%-10.6%).” (opens the source at this quote in a new tab)

Visual hallucinations: Charles Bonnet syndrome in a Danish neovascular AMD cohort

“Twenty-five (8.3%) patients of 300 had hallucinations attributable to CBS.” (opens the source at this quote in a new tab)

Psychiatric symptoms: mental health scores by visual acuity

“When stratified by VA, patients with a habitual VA of 20/200 or worse scored the lowest on mental health subscales scores: median of 43.8 (IQR: 31–62). Patients with a VA of 20/20 scored the highest: 87.5 (IQR: 81–94).” (opens the source at this quote in a new tab)

Functional symptoms: reading, face recognition, and driving

“AMD doesn’t cause complete blindness, but losing your central vision can make it harder to see faces, read, drive, or do close-up work like cooking or fixing things around the house.” (opens the source at this quote in a new tab)

Functional symptoms: impaired activities of daily living at presentation

“The prevalence of impaired basic, instrumental and total ADL was 37.76%, 67.82% and 39.59%, respectively.” (opens the source at this quote in a new tab)

“Depressive symptoms [OR 2.08, 95% CI (1.08–4.00)], the presence of any disability [OR 3.16, 95% CI (1.64–0.07)] and never driving [OR 4.00, 95% CI (1.60–10.00)] were also positively associated with total ADL impairment.” (opens the source at this quote in a new tab)

Functional symptoms: falls

“Loss of VA increases the risk of frequent falls.” (opens the source at this quote in a new tab)

“About 10% of prevalent patients had a fall/fracture claim over 12 months of follow-up.” (opens the source at this quote in a new tab)