Older adults: LUGANO baseline age
Pregnancy, lactation, and contraception
Cardiovascular, bleeding, and metabolic exclusion criteria (phase 2)
“Uncontrolled blood pressure (defined as systolic >180 mmHg and/or diastolic >100 mmHg), based on the average of three readings taken with the subject in a resting state.” (opens the source at this quote in a new tab)
“Myocardial infarction within 6 months prior to screening or New York Hospital Association (NYHA) Class III or IV heart failure, uncontrolled atrial fibrillation, uncontrolled angina, cardiomyopathy, ventricular arrhythmias or other cardiac conditions which, in the judgment of the investigator, could make the subject inappropriate for entry into this study.” (opens the source at this quote in a new tab)
“HbA1c greater than 7% at the Screening Visit.” (opens the source at this quote in a new tab)
“History or presence of bleeding disorders, including platelet disorders, hemorrhage, acquired or hereditary coagulation disorders (including deep vein thrombosis and pulmonary embolisms), acquired or hereditary vascular disorders, stroke, or transient ischemic attack.” (opens the source at this quote in a new tab)
Pediatric use, hepatic impairment, and renal impairment
No evidence found.