Name: Lirafugratinib (Lyrfigtu) in Previously treated FGFR2 fusion or rearrangement-positive cholangiocarcinoma: Perspective and time frame
Published: 2026-09-27T09:44:05-04:00

Budget impact model of lirafugratinib: perspective and time frame

No evidence found.

Perspectives and time horizons used in economic evaluations of advanced biliary tract cancer

“Most cost-effectiveness studies adopted a healthcare-payer or healthcare-system perspective, while only a minority explicitly incorporated broader societal costs such as productivity loss.” (opens the source at this quote in a new tab)

“Hence, with reference to the dosing cycle of the TOPAZ-1 clinical trial, we set the cycle of the Markov model to 21 days and the time horizon of 10 years to simulate the entire life course of the patient” (opens the source at this quote in a new tab)
“This research was based on the perspective of Chinese and US payers, applying discount rates of 3% and 5% to costs and utilities, respectively” (opens the source at this quote in a new tab)

“This analysis adopted the health care perspectives of third-party payers in China and the US, respectively.” (opens the source at this quote in a new tab)
“In China, costs (converted to US dollars) and utilities were discounted at 5%, whereas in the United States, both costs and utilities were discounted at 3%” (opens the source at this quote in a new tab)

Perspectives, time horizons, and discount rates used in economic evaluations of FGFR inhibitors in cholangiocarcinoma

“A three-state partitioned survival model with a 5-year time horizon was constructed for patients with advanced intrahepatic cholangiocarcinoma who did not respond to first-line therapy.” (opens the source at this quote in a new tab)
“The willingness-to-pay threshold was three times the gross domestic product per capita in 2021 (NT$2,889,684).” (opens the source at this quote in a new tab)

“The willingness-to-pay threshold was three times the forecasted gross domestic product per capita in 2022 (NT$2,928,570).” (opens the source at this quote in a new tab)
“A 3% discount rate was applied to quality-adjusted life-years (QALYs) and costs.” (opens the source at this quote in a new tab)

“All future outcomes were discounted at 3.5% per annum.” (opens the source at this quote in a new tab)

“An ICER below the threshold of $50,000 is considered to have high value and is cost-effective, while an ICER above the threshold of $150,000 is considered to have low value and is not cost-effective.” (opens the source at this quote in a new tab)

Time horizon and willingness-to-pay threshold in the Taiwanese cost-effectiveness analysis of a biomarker-driven pemigatinib regimen

“To avoid overestimating clinical efficacy from extrapolating survival curves, we used a 5-year horizon instead of a lifetime horizon.” (opens the source at this quote in a new tab)
“Because there was no official WTP threshold in Taiwan, the WTP threshold was three times the gross domestic product per capita in 2021 (NT$2,889,684) recommended by the World Health Organization” (opens the source at this quote in a new tab)