Name: Lirafugratinib (Lyrfigtu) in Previously treated FGFR2 fusion or rearrangement-positive cholangiocarcinoma: Dosage forms and strengths
Published: 2026-09-27T09:44:05-04:00

Product information and disease description Product description Product information

Dosage forms and strengths

4 evidence topics · 2 sources

Capsule strengths and appearance

“Capsules: 20 mg and 30 mg.” (opens the prescribing information at this quote)
“20 mg: Opaque, white, size 3 capsules with “LIR” printed in black ink on the cap and “20 mg” printed in black ink on the body.” (opens the prescribing information at this quote)
“30 mg: Opaque, size 2 capsules with olive green cap and white body, with “LIR” printed in black ink on the cap and “30 mg” printed in black ink on the body.” (opens the prescribing information at this quote)

Salt content and inactive ingredients

“Each 20 mg LYRFIGTU capsule contains 21.43 mg of lirafugratinib hydrochloride (approximately 20 mg of lirafugratinib base), and each 30 mg LYRFIGTU capsule contains 32.15 mg of lirafugratinib hydrochloride (approximately 30 mg of lirafugratinib base).” (opens the prescribing information at this quote)
“Both capsule strengths contain the following inactive ingredients: colloidal silicon dioxide, croscarmellose sodium, magnesium stearate, microcrystalline cellulose, and pregelatinized starch.” (opens the prescribing information at this quote)
“The capsule shell for both the 20 mg and 30 mg capsules includes gelatin, and titanium dioxide.” (opens the prescribing information at this quote)

Daily dose packs and national drug codes

“LYRFIGTU capsules are packaged in blister cards and supplied in child-resistant DosePaks” (opens the prescribing information at this quote)

Daily dose package	Carton contents	NDC
70 mg daily dose	“2 blister packs containing twenty-eight 20 mg capsules and fourteen 30 mg capsules each”	“82827-070-01”
50 mg daily dose	“2 blister packs containing fourteen 20 mg capsules and fourteen 30 mg capsules each”	“82827-050-01”
40 mg daily dose	“2 blister packs containing twenty-eight 20 mg capsules each”	“82827-040-01”
30 mg daily dose	“1 blister pack containing twenty-eight 30 mg capsules”	“82827-030-01”
20 mg daily dose	“1 blister pack containing twenty-eight 20 mg capsules”	“82827-020-01”

Storage and expiry dating

“Store at 20°C to 25°C (68°F to 77°F); excursions permitted to 15°C to 30°C (59°F to 86°F)” (opens the prescribing information at this quote)

“Based on the stability data submitted to date, the expiry dating period for Lyrfigtu (lirafugratinib) capsule shall be 36 months from the date of manufacture when stored at 20°C to 25°C (68°F to 77°F)” (opens the source at this quote in a new tab)