Chronic treatment of mitochondrial disease with dichloroacetate
7 evidence topics · 2 sources
Objective
Location and study date
Reported treatment duration
Study design
Eligibility criteria
No evidence found.
Treatment
Study outcomes
Rationale for using blood and cerebrospinal fluid lactate as the biochemical outcomes
No evidence found.
Statistical analysis description
Number of participants (Planned and analyzed)
Cohort size and diagnostic heterogeneity
Description of analysis sets
No evidence found.
Results
Participant disposition
No evidence found.
Baseline characteristics
No evidence found.
Efficacy results
Health-related quality of life and patient-reported outcomes
No evidence found.
Safety results
No evidence found.
Study limitations
Summary
The study followed 37 participants with various mitochondrial disorders using an open-label format and variable treatment duration. These observations do not provide a randomized estimate of treatment effect in PDCD. Diagnostic heterogeneity and unblinded outcome assessment limit attribution of neurologic changes to dichloroacetate.