Effect of sodium dichloroacetate on human pyruvate metabolism

6 evidence topics · 1 source

Objective

Location and study date

No evidence found.

Study design

Single-participant observation

“a patient” (opens the source at this quote in a new tab)

Eligibility criteria

No evidence found.

Treatment

Oral dose and administration frequency

“12.5 to 50 mg/kg body weight twice or three times per day” (opens the source at this quote in a new tab)

Study outcomes

Rationale for using lactate during exercise as a biochemical outcome

No evidence found.

Statistical analysis description

Number of participants (Planned and analyzed)

Reported participant

“a patient” (opens the source at this quote in a new tab)

Description of analysis sets

Not applicable.

Results

Participant disposition

No evidence found.

Baseline characteristics

Underlying mitochondrial disorder

“mitochondrial encephalomyopathy associated with congenital lactic acidemia” (opens the source at this quote in a new tab)

Efficacy results

Exercise-associated lactate response

“increases in the lactate levels in the blood and urine during exercise were markedly reduced.” (opens the source at this quote in a new tab)

Health-related quality of life and patient-reported outcomes

No evidence found.

Safety results

No evidence found.

Study limitations

Summary

This is a single-participant pharmacologic observation in mitochondrial encephalomyopathy with congenital lactic acidemia. The report does not provide a randomized comparison or establish that the participant had the target PDCD diagnosis. The exercise-related biochemical response therefore provides indirect evidence rather than an estimate of SL1009 clinical efficacy in PDCD.