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Tirabrutinib

Primary central nervous system lymphoma

Regulatory submission
NDA submitted December 2025
72 sources

Section 1 of 6

Terms and abbreviations

1 evidence topic · 0 sources

AbbreviationTerm
AAPCAverage annual percent change
ADRAdverse drug reaction
AEAdverse event
AHFSAmerican Hospital Formulary Service
AKTProtein kinase B
ASCTAutologous stem cell transplantation
ATCAnatomical Therapeutic Chemical
AUCArea under the concentration-time curve
BORBest overall response
BTKBruton tyrosine kinase
CAR-TChimeric antigen receptor T-cell
CASChemical Abstracts Service
CD79BCluster of differentiation 79B
CIConfidence interval
CLLChronic lymphocytic leukemia
CNSCentral nervous system
CRComplete response
CRuUnconfirmed complete response
CSFCerebrospinal fluid
CYPCytochrome P450
DLBCLDiffuse large B-cell lymphoma
DORDuration of response
EANOEuropean Association of Neuro-Oncology
ECOGEastern Cooperative Oncology Group
EHAEuropean Hematology Association
EORTCEuropean Organisation for Research and Treatment of Cancer
EQ-5DEuroQol five-dimension questionnaire
ERKExtracellular signal-regulated kinase
ESMOEuropean Society for Medical Oncology
FDAFood and Drug Administration
HDCHigh-dose chemotherapy
HD-MTXHigh-dose methotrexate
HRQoLHealth-related quality of life
ILDInterstitial lung disease
IPCGInternational Primary CNS Lymphoma Collaborative Group
IRCIndependent review committee
JCOGJapan Clinical Oncology Group
JPYJapanese yen
KPSKarnofsky Performance Status
MCLMantle cell lymphoma
MRIMagnetic resonance imaging
MTRMethotrexate, temozolomide, and rituximab
MTXMethotrexate
MYD88Myeloid differentiation primary response 88
NDANew drug application
ORROverall response rate
OSOverall survival
P-gpP-glycoprotein
PBCPrimary biliary cholangitis
PCNSLPrimary central nervous system lymphoma
PDUFAPrescription Drug User Fee Act
PFSProgression-free survival
PKPharmacokinetics
PMDAPharmaceuticals and Medical Devices Agency
PRPartial response
QoLQuality of life
R-MPVRituximab, methotrexate, procarbazine, and vincristine
R/RRelapsed or refractory
rwPFSReal-world progression-free survival
SDStable disease
SJSStevens-Johnson syndrome
TEAETreatment-emergent adverse event
TENToxic epidermal necrolysis
TIRTirabrutinib
TRAETreatment-related adverse event
TWDNew Taiwan dollar
USDUnited States dollar
WBRTWhole-brain radiotherapy
WMWaldenström macroglobulinemia