Evicenter
P&T meetings

Zanzalintinib (XL092)

Metastatic colorectal cancer

Manufacturer
Exelixis
Regulatory submission
NDA submitted December 2025
Launch
Not announced
Last updated
65 sources

Product information and disease descriptionPlace of product in therapyApproaches to treatment

Place in treatment, anticipated use, and care setting

1 evidence topic · 3 sources

Summary

The proposed population comprises adults previously treated with fluoropyrimidine-, oxaliplatin-, and irinotecan-based chemotherapy, with prior anti-EGFR therapy for RAS wild-type disease. The pivotal regimen combines daily oral zanzalintinib with intravenous atezolizumab every three weeks. This is an investigational treatment position, not an approved prescribing recommendation or established commercial access pathway.