Name: Aqneursa (levacetylleucine) in Ataxia-telangiectasia: Respiratory care
Published: 2026-10-02T18:22:10-04:00

Product information and disease description Place of product in therapy Approaches to treatment Current treatment options and standard of care

Respiratory care

6 evidence topics · 5 sources

Evidence base for respiratory management

“There are no randomised controlled trials with respect to the treatment of the respiratory complications in A-T.” (opens the source at this quote in a new tab)
“Current approaches are based on minimal best available evidence in A-T, and extrapolation from other more common disorders such as cystic fibrosis.” (opens the source at this quote in a new tab)

Lung function monitoring

“Regular assessments at least twice a year provide an impression of the degree of lung decline and allows for proactive early intervention.” (opens the source at this quote in a new tab)

“Children with A-T should undergo annual lung function studies starting at 6 years of age.” (opens the source at this quote in a new tab)
“These interventions may include the initiation of a cough assist device and chest physiotherapy to help improve MCC and lung inflation.” (opens the source at this quote in a new tab)

Airway clearance and cough augmentation

“Regular airway clearance and measures to augment cough and mucociliary clearance is advised by most experts looking after children with A-T.” (opens the source at this quote in a new tab)

“Respiratory muscle strength training, chest physiotherapy, and cough-assist devices can be useful in improving pulmonary function and reducing aspiration.” (opens the source at this quote in a new tab)

Antibiotic treatment of respiratory symptoms

“Administration of antibiotics should be considered when children and adults have prolonged respiratory symptoms (greater than 7 days) following a respiratory illness, including those that begin with a viral illness.” (opens the source at this quote in a new tab)

Interstitial lung disease

“Progressive, diffuse lung disease that poorly responds to aggressive antibiotic therapy, physiotherapy and immunoglobulin replacement and to which aspiration does not seem to contribute should lead to consideration of noninfective causes of lung disease in A-T, including ILD and pulmonary fibrosis and early treatment with corticosteroids.” (opens the source at this quote in a new tab)

Inspiratory muscle training: study in 11 participants

“A longitudinal study was conducted with 11 AT patients and nine healthy volunteers.” (opens the source at this quote in a new tab)
“The health and vitality domains of the SF-36 also showed significant improvement (P = 0.009 and P = 0.014, respectively) post-IMT.” (opens the source at this quote in a new tab)