Name: Azetukalner (XEN1101) in Focal onset seizures: Alpha-2-Delta calcium channel ligands
Published: 2026-09-21T21:41:53-04:00

Product information and disease description Place of product in therapy Approaches to treatment Current treatment options and standard of care

Alpha-2-Delta calcium channel ligands

4 evidence topics · 4 sources

Pregabalin in treatment-resistant adult focal epilepsy

“For TRAFE, immediate-release PGB and PER are established as effective to reduce seizure frequency (Level A).” (opens the source at this quote in a new tab)

Mechanistic basis of the alpha-2-delta ligand class

“Of them, levetiracetam and brivaracetam show a high affinity to the synaptic vesicle protein type 2 A (SV2A), whereas pregabalin and gabapentin are selective ligands for the α2δ1 subunits of the voltage-gated calcium channels.” (opens the source at this quote in a new tab)

Adjunctive pregabalin: pooled efficacy

“For the primary outcome, participants randomised to pregabalin were significantly more likely to attain a 50% or greater reduction in seizure frequency compared to placebo (RR 1.95, 95% CI 1.40 to 2.72, 9 trials, 2663 participants, low-certainty evidence).” (opens the source at this quote in a new tab)
“Pregabalin was significantly associated with seizure freedom (RR 3.94, 95% CI 1.50 to 10.37, 4 trials, 1125 participants, moderate-certainty evidence).” (opens the source at this quote in a new tab)
“For people with drug-resistant focal epilepsy, pregabalin when used as an add-on treatment was significantly more effective than placebo at producing a 50% or greater seizure reduction and seizure freedom.” (opens the source at this quote in a new tab)

Comparative tolerability of gabapentin

“The evidence suggested that lamotrigine, levetiracetam and gabapentin may have more tolerable adverse events than other drugs.” (opens the source at this quote in a new tab)