Name: Azetukalner (XEN1101) in Focal onset seizures: Economic impact of Focal onset seizures on families
Published: 2026-09-21T21:41:53-04:00

Product information and disease description Place of product in therapy Disease description Burden of Focal onset seizures

Economic impact of Focal onset seizures on families

4 evidence topics · 3 sources

Caregiver health care costs and absenteeism in focal onset seizures

“Sick days were significantly lower in the monotherapy cohort (2.4 days vs 4.4 days annually; P <.0001), with an associated cost difference of $541.” (opens the source at this quote in a new tab)
“Caregivers of patients with partial-onset seizures in the adjunctive therapy cohort had significantly greater medical and sick day costs than caregivers in the monotherapy cohort.” (opens the source at this quote in a new tab)
“These findings suggest that higher treatment burden among patients with epilepsy is associated with greater direct and indirect healthcare costs for their caregivers.” (opens the source at this quote in a new tab)

Caregiver work loss by treatment regimen

“A 2018 study found that caregivers of people on monotherapy had an average of 2.7 days of work lost annually due to sick leave and short-term disability. In contrast, the caregivers to those on adjunctive therapy had an average of 5.1 days of work lost annually due to the same reasons” (opens the source at this quote in a new tab)
“Sick leave in caregivers of those on monotherapy was associated with average costs of $582; whereas, in the adjunctive therapy caregivers group, this increased to $1123.” (opens the source at this quote in a new tab)

Caregiving time and caregiver distress

“In a 2014 study in which 92% of people had focal seizures, a higher caregiver burden was associated with the individuals taking a higher number of ASMs, lower neuropsychological performance, lower QoL score, and lower caregiver education level.” (opens the source at this quote in a new tab)
“On average, 11.4 (±21.2) h were spent on care per week, with the majority (58.3%) of caregivers being a spouse/partner” (opens the source at this quote in a new tab)
“Caregivers of adults with epilepsy experience extreme psychological distress and poor QoL” (opens the source at this quote in a new tab)
“The results suggest that 72% of caregivers strongly agree that they fear another seizure, irrespective of when the last episode was.” (opens the source at this quote in a new tab)

Caregiver productivity loss and health-related quality of life

“Caregivers similarly reported high productivity loss and absenteeism related to caregiving duties.” (opens the source at this quote in a new tab)
“In another international cross-sectional study of caregivers of adults with uncontrolled drug-resistant focal-onset seizures, caregivers reported the greatest problems (moderate, severe, or extreme problems) in anxiety/depression (44% of caregivers) and pain/discomfort (40%).” (opens the source at this quote in a new tab)