Product information and disease description Place of product in therapy Disease description Burden of Focal onset seizures

Humanistic burden and health-related quality of life

6 evidence topics · 3 sources

Instruments used to measure health-related quality of life in focal epilepsy

“Ten instruments evaluating HRQOL in people with focal epilepsy were identified, of which four were epilepsy-specific” (opens the source at this quote in a new tab)
“HRQOL was also worse, often significantly so, in people with epilepsy and psychiatric disorders, particularly depression, than in those without psychiatric disorders.” (opens the source at this quote in a new tab)

Quality of life by treatment response in focal epilepsy

Population	Quoted mean QOLIE-31-P total score with standard deviation
Focal epilepsy, drug resistant (n = 184)	“56.4 (18.7)”
Focal epilepsy, drug responsive (n = 53)	“70.8 (13.3)”
Comparison of the two groups	“<0.0001”

Stigma

“Almost one quarter (23.8%) of people with epilepsy reported having felt enacted stigma” (opens the source at this quote in a new tab)
“Stigma was associated with family and social support and employment; with increasing perceptions of stigma associated with worse family functioning or unemployment/low employability.” (opens the source at this quote in a new tab)
“Perceived stigma was experienced similarly by both people with epilepsy and their caregivers.” (opens the source at this quote in a new tab)

Seizure freedom and quality of life

“People seizure-free for more than 1 year have a significantly higher preference-based HRQoL than those in any other seizure frequency group.” (opens the source at this quote in a new tab)
“Further differentiation of QoL at higher response levels has been reported, with people achieving high response rates (particularly ≥90%) exhibiting higher QoL than people with ≤50% response rates” (opens the source at this quote in a new tab)
“This suggests that for a significant QoL improvement, seizure freedom must be attained and maintained” (opens the source at this quote in a new tab)

Determinants of reduced quality of life

“Some risk factors for reduced QoL have been identified, including frequent seizures, longer seizure duration, convulsions, and earlier age of onset” (opens the source at this quote in a new tab)
“Other factors affecting QoL include ASM side effects, depression or anxiety, lack of social support, stigma, and employment concerns” (opens the source at this quote in a new tab)
“Adults with epilepsy are likely to report more mentally and physically unhealthy days per month than those without epilepsy, with the highest rates in those with seizures in the past 3 months” (opens the source at this quote in a new tab)

Health utilities by seizure frequency in United States adults with focal epilepsy

Seizure frequency group, United States, unadjusted	Quoted mean SF-6D health utility with standard deviation
Total sample (n = 345)	“0.67 ± 0.14”
At least once a week (n = 55)	“0.63 ± 0.14”
One to three times a month (n = 68)	“0.65 ± 0.15”
One to four times a year (n = 71)	“0.67 ± 0.13”
Less than once a year (n = 151)	“0.70 ± 0.14”
p value for relationship to seizure frequency	“0.006”