Name: BIM-IOL System in Open-angle glaucoma or ocular hypertension: Pathophysiology
Published: 2026-09-17T18:17:42-04:00

Product information and disease description Place of product in therapy Disease description

Pathophysiology

4 evidence topics · 1 source

Aqueous humor dynamics and intraocular pressure

“Although the pathogenesis of glaucoma is not fully understood, the level of intraocular pressure is related to retinal ganglion cell death.” (opens the source at this quote in a new tab)
“In patients with open-angle glaucoma, there is increased resistance to aqueous outflow through the trabecular meshwork.” (opens the source at this quote in a new tab)

Mechanical stress at the lamina cribrosa and axonal transport

“The sclera is perforated at the lamina where the optic nerve fibers (retinal ganglion cell axons) exit the eye. The lamina is the weakest point in the wall of the pressurized eye. Intraocular pressure–induced stress and strain may result in compression, deformation, and remodeling of the lamina cribrosa with consequent mechanical axonal damage and disruption of axonal transport” (opens the source at this quote in a new tab)

Pressure-independent mechanisms

“Glaucomatous optic neuropathy can occur in individuals with intraocular pressures within the normal range. In such patients, there may be an abnormally low cerebrospinal fluid pressure in the optic nerve subarachnoid space resulting in a large pressure gradient across the lamina.” (opens the source at this quote in a new tab)
“Impaired microcirculation, altered immunity, excitotoxicity, and oxidative stress may also cause glaucoma.” (opens the source at this quote in a new tab)

Pattern of retinal ganglion cell loss and visual field damage

“Retinal ganglion cell loss causes progressive deterioration of visual fields, which usually begins in the midperiphery and may progress in a centripetal manner until there remains only a central or peripheral island of vision.” (opens the source at this quote in a new tab)