Cytisine versus nortriptyline

9 evidence topics · 1 source

Objective

Comparative objective

“smoking cessation” (opens the source at this quote in a new tab)

Location and study date

No evidence found.

Study design

Trial design

“multicentre, randomized, double-blinded, placebo-controlled trial” (opens the source at this quote in a new tab)

Eligibility criteria

Eligibility thresholds

Characteristic	Quoted value
Minimum age, years	“20”
Minimum cigarettes per day	“10”

Treatment

Treatment courses

Characteristic	Quoted value
Cytisine	“25-day”
Nortriptyline	“12-week”

Study outcomes

Rationale for using continuous smoking abstinence as the primary endpoint

Primary outcome

“biochemically verified continuous abstinence rate” (opens the source at this quote in a new tab)

Statistical analysis description

Number of participants (Planned and analyzed)

Randomized participants

Characteristic	Quoted value
Total	“1086”
Cytisine	“540”
Nortriptyline	“546”

Description of analysis sets

No evidence found.

Results

Participant disposition

No evidence found.

Baseline characteristics

No evidence found.

Efficacy results

Continuous abstinence at 12 months

“The 12-month CAR was 12.22% for cytisine and 9.52% for nortriptyline” (opens the source at this quote in a new tab)
“the relative risk was 1.28 (95% CI; 0.91–1.81).” (opens the source at this quote in a new tab)

Health-related quality of life and patient-reported outcomes

No evidence found.

Safety results

Adverse-event characterization

“minimal and well-tolerated.” (opens the source at this quote in a new tab)

Study limitations

Summary

The observed relative-risk confidence interval, 0.91–1.81, includes no difference. The nonsignificant comparison does not by itself establish equivalence. Cytisine and nortriptyline were administered for different durations.