Retrospective comparative-effectiveness cohort

11 evidence topics · 1 source

Objective

Clinical objective

“smoking cessation” (opens the source at this quote in a new tab)

Location and study date

Study country

“Türkiye” (opens the source at this quote in a new tab)

Study design

Treatment allocation

“Treatment allocation was based on routine clinical practice rather than randomization.” (opens the source at this quote in a new tab)

Eligibility criteria

Adult eligibility

Characteristic	Quoted value
Minimum age, years	“18”

Treatment

Medication groups

Characteristic	Quoted value
Treatments compared	“cytisine, bupropion, and nicotine replacement therapy”

Study outcomes

Rationale for using self-reported smoking abstinence as a study endpoint

Abstinence ascertainment

“self-reported” (opens the source at this quote in a new tab)

Statistical analysis description

Number of participants (Planned and analyzed)

Analyzed participants

Characteristic	Quoted value
Total cohort	“113”

Description of analysis sets

Adjustment limitation

“multivariable modeling was not performed.” (opens the source at this quote in a new tab)

Results

Participant disposition

No evidence found.

Baseline characteristics

No evidence found.

Efficacy results

Treatment adherence and outcome

“Treatment adherence emerged as a key determinant of cessation outcomes.” (opens the source at this quote in a new tab)

Overall cessation

Characteristic	Quoted value
Participants classified as quitters	“67”
Participants classified as non-quitters	“46”

Health-related quality of life and patient-reported outcomes

No evidence found.

Safety results

No evidence found.

Study limitations

Summary

Treatment selection reflected routine practice rather than randomization, and multivariable modeling was not performed. The association between adherence and cessation does not establish a causal medication effect or an adjusted comparative treatment effect.