Product information and disease description / Place of product in therapy2.2.1Disease description60 evidence topics · 22 sources2.2.1.1Definition and etiology4 evidence topics · 3 sources2.2.1.2Epidemiology9 evidence topics · 6 sources2.2.1.3Natural history, survival, and mortality8 evidence topics · 4 sources2.2.1.4Pathophysiology3 evidence topics · 3 sources2.2.1.5Diagnosis9 evidence topics · 11 sources2.2.1.6Clinical presentation - signs and symptoms10 evidence topics · 7 sources2.2.1.7Long-term morbidity5 evidence topics · 2 sources2.2.1.8Burden of MCT8 deficiency12 evidence topics · 8 sources