Juvmo (tavapadon)

A meta-analysis of North American cohorts estimated approximately 60,000 to 95,000 new Parkinson's disease diagnoses per year among adults aged 45 years and older. A second meta-analysis estimated a U.S. prevalence of 572 per 100,000 among people aged 45 years and older, or 680,000 individuals in 2010, rising to approximately 930,000 in 2020. A U.S. analysis estimated approximately one million people with diagnosed Parkinson's disease in 2017 and a total economic burden of $51.9 billion. In an incident cohort, the cumulative incidence of motor fluctuations was 54.3% at 5 years and 100% at 10 years, and that of levodopa-induced dyskinesia was 14.5% and 55.7%, respectively.