Product information and disease description Place of product in therapy Disease description Burden of Open-angle glaucoma or ocular hypertension

Humanistic burden and health-related quality of life

6 evidence topics · 7 sources

Guideline statement: quality of life across disease stages

“Quality of life is affected for patients with all stages of glaucoma, even those with early disease.” (opens the source at this quote in a new tab)

Vision-related quality of life by visual field loss: Ocular Hypertension Treatment Study, 20-year follow-up

“Of 1636 participants originally enrolled in the OHTS, 679 (42%) completed the 20-year examination and VRQoL surveys.” (opens the source at this quote in a new tab)
“The mean (SD) Rasch-calibrated total VFQ scores were 72.5 (13.4) in the no POAG group (control) vs 72.7 (13.8) in the unilateral disc POAG group (difference, 0.17; 95% CI, -3.17 to 3.41; P = .92), 73.4 (14.0) in the bilateral disc POAG group (difference, 0.92; 95% CI, -2.93 to 4.77; P = .64), 69.2 (14.5) in the unilateral VF POAG group (difference, 3.33; 95% CI, -6.38 to -0.27; P = .03), and 58.5 (16.9) in the bilateral VF POAG group (difference, -13.96; 95% CI, -17.73 to -10.19; P<.001).” (opens the source at this quote in a new tab)

Vision-related quality of life and visual impairment: Early Manifest Glaucoma Trial, 20-year follow-up

“NEI VFQ-25 scores were significantly higher for patients with no visual impairment (mean 73 ± 22) than for visually impaired patients (mean 31 ± 15, p < 0.001). VFI worse than 50% or MD worse than -18 dB was significantly associated with low VRQOL scores (p < 0.001).” (opens the source at this quote in a new tab)

Health-related quality of life by visual field loss: Los Angeles Latino Eye Study

“A trend of worse NEI-VFQ-25 scores for most subscales was observed with worse VF loss (using both monocular and calculated binocular data). Open-angle glaucoma participants with VF loss had lower scores than participants with no VF loss. This association was also present in participants who were previously undiagnosed and untreated for OAG (N = 160). Participants with any central VF loss had lower NEI-VFQ-25 scores than those with unilateral or bilateral peripheral VF loss. There was no significant impact of severity or location of VF loss on SF-12 scores.” (opens the source at this quote in a new tab)

Psychological burden of diagnosis and treatment

“The disease itself as well as the medical or surgical treatment can have an enormous impact on a patient's QoL. Even the mere diagnosis of a chronic, irreversible, potentially blinding disorder can adversely affect the patient's sense of well-being and QoL by eliciting significant anxiety.” (opens the source at this quote in a new tab)

“Sixteen studies including 14,030 glaucoma participants and 4,472,723 controls contributed to the primary odds ratio meta-analysis. Glaucoma was associated with higher odds of depression (OR, 2.80; 95% CI, 1.66-4.74; I 2 = 95.95%; approximate prediction interval 0.32-24.47).” (opens the source at this quote in a new tab)

Falls, fear of falling, and activity avoidance

“A greater risk of a high fear of falling and high avoidance of at-risk activities occurred at the moderate stage of glaucoma compared to controls (adjusted OR, 4.66; 95% CI, 1.24–17.49; p=0.023 and adjusted OR, 4.49; 95% CI, 1.34–15.05; p=0.015, respectively).” (opens the source at this quote in a new tab)