Name: Emcitate (tiratricol) in MCT8 deficiency: Administration
Published: 2026-09-14T15:39:06-04:00

Daily dosing schedule

“Administer the EMCITATE total daily dosage orally or by enteral feeding tube once daily or in two to three divided doses spread throughout the day.” (opens the prescribing information at this quote)
“The prepared EMCITATE suspension may be administered with or without food” (opens the prescribing information at this quote)

Preparation of the oral suspension

“Do not swallow, chew, or crush the tablets.” (opens the prescribing information at this quote)
“EMCITATE tablets for oral suspension must be dispersed in room temperature drinking water directly in a 10-12 mL syringe and given as a suspension only. Do not prepare with other liquids, food vehicles or enteral nutrition formulas.” (opens the prescribing information at this quote)
“If more than 3 tablets are needed for a single dose, divide the dose into multiple, separate preparations not to exceed 3 tablets per preparation.” (opens the prescribing information at this quote)
“Discard the suspension 30 minutes after preparation if not used.” (opens the prescribing information at this quote)
“EMCITATE tablets for oral suspension have a functional score line and can be split into equal halves.” (opens the prescribing information at this quote)

Enteral feeding tube administration

“Prepared EMCITATE suspension can be administered through an enteral feeding tube directly into the stomach. Either nasogastric (NG) tubes (6 French and above) or gastrostomy (G) tubes (12 French and above) can be used.” (opens the prescribing information at this quote)
“For enteral feeding tube administration, prepare the oral suspension based on tube size.” (opens the prescribing information at this quote)

Divided dosing: published management recommendations

“The total daily dose may be administered in one to three divided doses, and dose escalation should not exceed 80 µg/kg/day in patients weighing 10–40 kg, 60 µg/kg/day in those weighing 40–60 kg, and 50 µg/kg/day in patients weighing >60 kg” (opens the source at this quote in a new tab)

European Union administration: dispersion volume and feeding tubes

“The dispersion should be prepared in a dedicated small glass, by dispersing the tablet(s) (maximum 4 tablets at each dosing occasion) in 30 mL of drinking water, by stirring with a teaspoon for 1 minute.” (opens the source at this quote in a new tab)
“The contents of the syringe should be administered immediately into the gastroenteral feeding tube (30 mL + 10 mL for all age groups).” (opens the source at this quote in a new tab)
“The product has been tested using a percutaneous endoscopic gastrostomy (PEG) silicone tube (lumen 12 French, maximum length 34 cm), and nasogastric (NG) polyurethane tubes (lumen 6 French and 8 French, maximum length 56 cm). This product has not been tested with other types of tubes or tube materials.” (opens the source at this quote in a new tab)