Juvmo (tavapadon)

“We used the placeholder price and the threshold prices (at $50,000, $100,000, $150,000, and $200,000 per evLY gained) for tavapadon in these estimates.” (opens the source at this quote in a new tab)CopyFlag

“Because tavapadon had not yet received regulatory approval, a placeholder price of $15,000 per year (as reported by IPD Analytics) was used as the intervention acquisition cost in both models. In Model 1, levodopa was costed at the median generic wholesale acquisition cost (WAC) from RED BOOK ($289 per year), consistent with ICER Reference Case guidance for generic agents.” (opens the source at this quote in a new tab)CopyFlag

“For Model 1, levodopa utilization was informed by the NMA, with the annual carbidopa/levodopa acquisition cost reflecting one 25 mg/100 mg tablet taken eight times daily. For Model 2, a market-basket approach reflected the mix of dopamine agonists used in practice, with annual acquisition costs based on ropinirole HCl 3 mg three times daily, pramipexole dihydrochloride IR 1 mg three times daily, and rotigotine 2 mg/24-hour transdermal patch once daily.” (opens the source at this quote in a new tab)CopyFlag

“When AZILECT is prescribed as monotherapy or as adjunct therapy in patients not taking levodopa, patients may start AZILECT at the recommended dose of 1 mg administered orally once daily.” (opens the source at this quote in a new tab)CopyFlag

“In patients taking levodopa, with or without other PD drugs (e.g., dopamine agonist, amantadine, anticholinergics), the recommended initial dose of AZILECT is 0.5 mg once daily. If the patient tolerates the daily 0.5 mg dose, but a sufficient clinical response is not achieved, the dose may be increased to 1 mg once daily.” (opens the source at this quote in a new tab)CopyFlag

“The recommended regimen for the administration of selegiline hydrochloride is 10 mg per day administered as divided doses of 5 mg each taken at breakfast and lunch.” (opens the source at this quote in a new tab)CopyFlag

“The recommended starting dosage of XADAGO is 50 mg administered orally once daily (at the same time of day), without regard to meals. After two weeks, the dosage may be increased to 100 mg once daily, based on individual need and tolerability.” (opens the source at this quote in a new tab)CopyFlag

“The recommended dose of entacapone is one 200 mg tablet administered concomitantly with each levodopa and carbidopa dose to a maximum of 8 times daily (200 mg x 8 = 1,600 mg per day).” (opens the source at this quote in a new tab)CopyFlag

“patients were randomized to receive placebo or entacapone 200 mg administered concomitantly with each dose of levodopa and carbidopa (up to 10 times daily, but averaging 4 doses to 6 doses per day)” (opens the source at this quote in a new tab)CopyFlag

“The recommended dosage of ONGENTYS is 50 mg administered orally once daily at bedtime.” (opens the source at this quote in a new tab)CopyFlag

“The recommended dosage of NOURIANZ is 20 mg administered orally once daily. The dosage may be increased to a maximum of 40 mg once daily, based on individual need and tolerability.” (opens the source at this quote in a new tab)CopyFlag

“The initial daily dosage of GOCOVRI is 137 mg, administered orally once daily at bedtime. After one week, increase to the recommended dosage of 274 mg (two 137 mg capsules) once daily at bedtime.” (opens the source at this quote in a new tab)CopyFlag