SL1009 (sodium dichloroacetate)

Pyruvate dehydrogenase complex deficiency

Manufacturer: Saol Therapeutics
Regulatory submission: NDA resubmitted June 2026
Launch: Not announced
Last updated: September 19, 2026

Section

Product information and disease description Place of product in therapy Approaches to treatment Current treatment options and standard of care

Ketogenic dietary therapy

5 evidence topics · 5 sources

Primary PDCD management

“Ketogenic diet is the gold-standard therapy for individuals with primary PDCD” (opens the source at this quote in a new tab)
“Tolerance of the ketogenic diet varies and treatment must be individualized.” (opens the source at this quote in a new tab)

Ketogenic-diet clinical evidence

“Nineteen patients were assessed” (opens the source at this quote in a new tab)

Ketogenic diet therapies: International Ketogenic Diet Study Group recommendations

“KDTs are the treatment of first choice for 2 distinct disorders of brain energy metabolism: Glut1DS and PDHD.” (opens the source at this quote in a new tab)

Ketogenic-diet literature review and clinical-practice survey

“Forty studies describing 129 patients were identified, predominantly case reports or series.” (opens the source at this quote in a new tab)

Reported use of ketogenic diet in a natural-history cohort

“The next most common intervention was dietary, with 60% (35/58) of the subjects reportedly having used a “ketogenic” diet at some time.” (opens the source at this quote in a new tab)
“Altogether, 83% (24/29) of responding families reported that use of a ketogenic diet was “very helpful”, 10% said it was “somewhat helpful”, and 7% reported that it was “not helpful”” (opens the source at this quote in a new tab)
“No significant correlation was found between use of ketogenic diets and survival or cognitive function outcomes, which is not surprising since use of ketogenic diets varied by degree of severity, duration, and age of administration.” (opens the source at this quote in a new tab)
“ketogenic diet therapy does not reverse prior neurological damage and is not effective in sustaining survival in the most severe cases of PDC deficiency.” (opens the source at this quote in a new tab)