Evicenter
P&T meetings

SL1009 (sodium dichloroacetate)

Pyruvate dehydrogenase complex deficiency

Manufacturer
Saol Therapeutics
Regulatory submission
NDA resubmitted June 2026
Launch
Not announced
Last updated
78 sources

Product information and disease descriptionPlace of product in therapyApproaches to treatmentCurrent treatment options and standard of care

Vitamin and cofactor supplementation

2 evidence topics · 2 sources

Thiamine supplementation

“thiamine (may benefit rare individuals)” (opens the source at this quote in a new tab)

Reported use of thiamine in a natural-history cohort

“Thiamine was the most frequently employed intervention, with 68% (39/57) of subjects reporting some use.” (opens the source at this quote in a new tab)

“Doses ranged widely from 25 mg to 2000 mg/day (average dose: 174 mg; median dose: 150 mg/dl).” (opens the source at this quote in a new tab)

“No subject reportedly had a remarkable beneficial response to thiamine treatment.” (opens the source at this quote in a new tab)