Name: Anaphylm (dibutepinephrine) in Type I allergic reactions including anaphylaxis: Cost assumptions
Published: 2026-09-21T21:39:21-04:00

Economic information and modeling report Budget impact model

Cost assumptions

5 evidence topics · 5 sources

Direct cost of anaphylaxis in the United States

“Direct cost of anaphylaxis is $1.2 billion” (opens the source at this quote in a new tab)

Market cost of an epinephrine auto-injector twin pack used in an economic evaluation

“At a market cost of $715 per twin pack, the autoinjector incremental cost-effectiveness ratio was $2 742 697 per quality-adjusted life-year.” (opens the source at this quote in a new tab)

Cost of branded compared with generic epinephrine auto-injectors over a 20-year horizon

“Assuming prescriptions written for 2 double epinephrine packs each year (home and school), the mean costs of food allergy over the 20-year model horizon totaled $58,667 (95% confidence interval [CI] $57,745-$59,588) when EpiPen was prescribed and $45,588 (95% CI $44,873-$46,304) when epinephrine injection, USP auto-injector was prescribed.” (opens the source at this quote in a new tab)
“Cost differences among epinephrine auto-injectors were significant. More expensive auto-injector brands did not appear to provide incremental benefit.” (opens the source at this quote in a new tab)

Device cost thresholds at which alternative prescribing strategies become cost-effective

“However, the universal strategy became cost-effective versus a multi-epi strategy when single EAI costs were less than $80, second epinephrine dose requirements more than 25.5%, anaphylaxis hospitalization costs more than $18,453, annual anaphylaxis risk more than 76.5%, or anaphylaxis hospitalization rate more than 74.9%.” (opens the source at this quote in a new tab)

Annual acquisition cost ceiling for undesignated stock epinephrine

“However, the cost of the supplemental model fell below $100 000 per QALY when the annual undesignated epinephrine acquisition costs did not exceed $338 per school (compared with stock epinephrine unavailability).” (opens the source at this quote in a new tab)