Product information and disease description Place of product in therapy Disease description

Long-term morbidity

8 evidence topics · 8 sources

Recurrence of anaphylaxis in a population-based cohort followed for 10 years

“Eight percent of the patients experienced anaphylaxis recurrence within 10 years, (recurrence rate of 2.6 per 100 person-years) with most patients having the first recurrence within four years.” (opens the source at this quote in a new tab)
“There were 46 patients who experienced one recurrence, three patients who experienced two, and one patient who experienced eight during the time period under study, for a total of 60 recurrences observed during 2290 patient-years of follow-up, resulting in a recurrence rate of 2.6 per 100 person-years.” (opens the source at this quote in a new tab)
“Patients who experienced recurrent reactions typically experienced the recurrence in a relatively short time period, as the median time between the index and recurrent anaphylaxis was about seven months, with an interquartile range between 1 month and 4 years.” (opens the source at this quote in a new tab)

Recurrence of reactions reported across follow-up studies

“Worrying data indicate that recurrence of reactions occurs in 26.5–54.0% of anaphylaxis patients during a follow-up time of 1.5 years–25 years.” (opens the source at this quote in a new tab)

Early emergency department revisits after pediatric anaphylaxis

“The median hospitalization rate was 3.5% (IQR 2.2, 6.0) and the 3-day ED revisit rate was 0.6% (IQR 0.4, 0.9).” (opens the source at this quote in a new tab)
“There were 6 fatalities reported during the study period and 0.6 % (IQR 0.4, 0.9) of patients discharged from the ED during the index encounter had a 3-day ED revisit for anaphylaxis of which 11.4% (n=31) were hospitalized.” (opens the source at this quote in a new tab)

Repeat emergency department treatment among individuals with food allergy

“More generally, recent US population-weighted survey data indicate that approximately 1 in 10 convincingly food-allergic individuals report receiving treatment for a food-allergic reaction in the emergency department within the past 12 months. Over 1 in 3 report that they have received food allergy treatment in the emergency department at some point in their lifetime.” (opens the source at this quote in a new tab)

Permanent neurological disability after near-fatal anaphylaxis

“The most devastating reactions result in death, or near-fatal episodes resulting in permanent neurological disability from hypoxic ischaemic encephalopathy.” (opens the source at this quote in a new tab)
“277 case studies and 14 case series were identified reporting 896 deaths and 28 disabilities.” (opens the source at this quote in a new tab)

Neurological outcome after out-of-hospital cardiac arrest caused by anaphylaxis

“Patients with OHCA-A had a significantly higher favourable neurological outcome rate (24.2% vs 11.7%, p<0.001) and higher survival rate at 1 month (33.2% vs 16.1%, p<0.001) than patients with OHCA-C.” (opens the source at this quote in a new tab)

Persistence and resolution of food allergy during childhood

“Allergies to peanuts, tree nuts, and seafood tend to persist, whereas those to cow’s milk, hen’s eggs, wheat, and soy are typically outgrown during the preschool years.” (opens the source at this quote in a new tab)
“From a relatively large-scale retrospective analysis of children with cow’s milk allergy in the United States with a median follow-up duration of 54 months, the resolution rates of cow’s milk allergy were 19% by 4 years, 42% by 8 years, 64% by 12 years, and 79% by 16 years” (opens the source at this quote in a new tab)

Adult-onset food allergy and severe reaction history among United States adults

“Among food-allergic adults, 51.1% (95% CI, 49.3%-52.9%) experienced a severe food allergy reaction, 45.3% (95% CI, 43.6%-47.1%) were allergic to multiple foods, and 48.0% (95% CI, 46.2%-49.7%) developed food allergies as an adult.” (opens the source at this quote in a new tab)