Name: Anaphylm (dibutepinephrine) in Type I allergic reactions including anaphylaxis: Manual intramuscular epinephrine and prefilled syringes
Published: 2026-09-21T21:39:21-04:00

Product information and disease description Place of product in therapy Approaches to treatment Current treatment options and standard of care

Manual intramuscular epinephrine and prefilled syringes

4 evidence topics · 3 sources

Prefilled syringe without auto-injector function

“The FDA has also approved the Symjepi epinephrine injection device, a prefilled syringe without autoinjector functionality.” (opens the source at this quote in a new tab)

Approved indication and dosing of the prefilled syringe

“SYMJEPI is intended for immediate administration in patients who are determined to be at increased risk for anaphylaxis, including individuals with a history of anaphylactic reactions.” (opens the source at this quote in a new tab)
“Injection: 0.3 mg (0.3 mg/0.3 mL), clear and colorless solution in single-dose, pre-filled syringe for manual injection” (opens the source at this quote in a new tab)
“Injection: 0.15 mg (0.15 mg/0.3 mL), clear and colorless solution in single-dose, pre-filled syringe for manual injection” (opens the source at this quote in a new tab)

Manual administration where auto-injectors are unavailable

“It is therefore necessary to explain to these patients why, when, and how to inject EAI or alternatives (such as marketed pre-filled epinephrine syringes or vials) where EAI are not available.” (opens the source at this quote in a new tab)

Cost position of syringes and ampules relative to auto-injectors

“In comparison, the average wholesale prices of generic EAIs, epinephrine prefilled syringes, and ampules of epinephrine are substantially lower.” (opens the source at this quote in a new tab)
“The Canadian Agency for Drugs and Technologies in Health recently reviewed the available research on the clinical and cost-effectiveness of EAIs vs manual epinephrine administration with an ampule/vial and syringe and found no relevant studies.” (opens the source at this quote in a new tab)