Product information and disease description Place of product in therapy Disease description Burden of Type I allergic reactions including anaphylaxis

Economic impact of diagnostic testing

6 evidence topics · 4 sources

Limited specificity of skin prick and specific IgE testing and the resulting cost of false positive results

“Despite the relatively high sensitivity of these tests, they have an estimated specificity of around 60%, potentially generating false positives and incurring unnecessary costs.” (opens the source at this quote in a new tab)

Direct charges and societal costs of an oral food challenge

“We also estimated the costs by utilizing Medicare physician fee schedule and device costs, and the amount (3 hours non-facility = $626.89 and 3 hours facility = $565.315) was close to the one obtained from fairhealthconsumer.org without including hospital outpatient fees (facility), which vary greatly.” (opens the source at this quote in a new tab)

Cost-effectiveness of confirmatory oral food challenges compared with food elimination

“The cost of OFC strategy was $8671 compared with $18 012 for the FE strategy for the length of the model.” (opens the source at this quote in a new tab)
“In the OFC strategy, the total cost was $9341 less than FE and the increase in QALY after OFCs led to a 0.202 higher effectiveness in the OFC strategy.” (opens the source at this quote in a new tab)

Cost of drug allergy evaluation with skin testing and drug challenge

“The base case penicillin allergy evaluation costs $220 in 2016 United States dollars: $98 for personnel, $119 for consumables, and $3 for space.” (opens the source at this quote in a new tab)
“In sensitivity analyses, lower cost estimates were achieved when only a drug challenge was performed (i.e., no skin test, $84) and a nurse practitioner provider was used ($170).” (opens the source at this quote in a new tab)

Range of costs across accounting methods for allergy evaluation

“The cost of penicillin allergy evaluation using the RCC method ranged from $225 (no E&M, 2-step challenge only) to $1,247 (two visits, penicillin skin test with ampicillin, 2-step challenge after skin testing).” (opens the source at this quote in a new tab)

Cost-effectiveness of screening infants before peanut introduction

“Early peanut introduction reduces the risk of developing peanut allergy, especially in high-risk infants. Current US recommendations endorse screening but are not cost-effective relative to other international strategies.” (opens the source at this quote in a new tab)
“In deterministic SPT sensitivity analyses at base-case sensitivity and specificity rates, screening could be cost-effective at a high disutility rate (the negative effect of a food allergic reaction) (76-148 days of life traded) for an at-home vs in-clinic reaction in combination with high baseline peanut allergy prevalence among infants at high risk for peanut allergy and not yet exposed to peanuts.” (opens the source at this quote in a new tab)