Product information and disease description Place of product in therapy Disease description Burden of Type I allergic reactions including anaphylaxis

Humanistic burden and health-related quality of life

7 evidence topics · 9 sources

Population-level food allergy quality-of-life impairment among United States adults measured with the Food Allergy Independent Measure

“The overall estimated mean FAIM score was 2.87 (95% confidence interval: 2.83-2.90).” (opens the source at this quote in a new tab)
“The population-level psychosocial burden of adults with FA is substantial, broadly distributed, and differs by demographic and allergic disease characteristics.” (opens the source at this quote in a new tab)

Clinical markers associated with greater quality-of-life impairment

“Reporting a current epinephrine autoinjector (EAI) prescription, severe allergic reaction history, history of EAI use, FA-related emergency department visits, or more FAs were also associated with significantly higher FAIM scores.” (opens the source at this quote in a new tab)

Caregiver-proxy psychosocial burden among United States children with food allergy

“The overall estimated mean caregiver-proxy FAIM scores for the US pediatric population were 2.79 (SE = 0.03) for reported FA, 2.96 (SE = 0.04) for convincing FA, and 3.21 (SE = 0.05) for physician-confirmed, convincing FA.” (opens the source at this quote in a new tab)
“While heterogenous to a degree, the psychosocial burden of children with FA was substantial irrespective of sociodemographic and clinical characteristics.” (opens the source at this quote in a new tab)

Caregiver anxiety, health utility, and quality-of-life decrement in peanut allergy

“Male and female caregivers reported mean levels of anxiety significantly higher than United Kingdom population norms.” (opens the source at this quote in a new tab)
“The utility decrement was largely driven by the EQ-5D anxiety and depression domain: 44% of caregivers reported being at least slightly anxious or depressed, compared with those reporting at least slight problems with self-care (7%), mobility (9%), usual activities (17%), and pain or discomfort (19%).” (opens the source at this quote in a new tab)

Health utilities derived from food allergy specific quality-of-life instruments

“However, traditional HRQoL instruments lack the sensitivity to generate health utilities that capture the impact that food allergies, such as peanut allergies, may have on children’s mental health and daily activities.” (opens the source at this quote in a new tab)
“The DCE disutilities were highest for severe food-related anxiety, emotional distress, and social limitations.” (opens the source at this quote in a new tab)
“The mean health utility for the actual EQ-5D-3L responses was 0.8431 (SD: 0.202, range: 0.193 to 1).” (opens the source at this quote in a new tab)

Social restriction and reliance on epinephrine auto-injectors in daily management

“Previous research describes how the stress of daily food allergy management compounded by the dearth of effective treatment options impacts family relationships and often limits social activities, ultimately contributing to impaired food allergy-related quality of life.” (opens the source at this quote in a new tab)
“Moreover, among these same food-allergic individuals, 1 in 5 report having treated a food-allergic reaction with an epinephrine auto-injector with the highest rates of epinephrine auto-injector (EAI) use reported among food-allergic adolescents and young adults.” (opens the source at this quote in a new tab)

Reported epinephrine auto-injector carriage rates and device-related concerns

“Despite this, studies have revealed that only about half of patients regularly carry an unexpired EAI.” (opens the source at this quote in a new tab)
“These anticipated reactions may be layered on top of other preexisting worries among patients with severe allergic reactions and their caregivers about when to use the EAI, potential side effects, needle phobias, and the force required to inject the drug.” (opens the source at this quote in a new tab)

“Barriers to AAI carriage were believed to be inconvenience of the size and difficulty of use.” (opens the source at this quote in a new tab)
“Some were embarrassed of their AAIs and less likely to carry them because of shame, fear of being seen as different or irritation at having to explain themselves.” (opens the source at this quote in a new tab)