Product information and disease description Place of product in therapy Disease description Epidemiology

Incidence of Type I allergic reactions including anaphylaxis

8 evidence topics · 8 sources

Worldwide incidence of anaphylaxis and the range reported in children

“Recent publications show a global incidence of anaphylaxis between 50 and 112 episodes per 100 000 person-years while the estimated lifetime prevalence is 0.3–5.1%, variations depending on the definitions used, study methodology, and geographical areas.” (opens the source at this quote in a new tab)
“According to a recent systematic review, in children, the incidence of anaphylaxis ranged from 1 to 761 per 100 000 person-years.” (opens the source at this quote in a new tab)

Pooled population-based incidence of all-cause anaphylaxis and its annual rate of increase

“The current incidence worldwide was found to be approximately 46 cases per 100,000 population per year (95% CI 21–103).” (opens the source at this quote in a new tab)
“Using a random effects Poisson model we calculated a yearly increase of anaphylaxis incidence by 7.4% (95% CI 7.3–7.6, p < 0.05).” (opens the source at this quote in a new tab)

United States emergency department visits for anaphylaxis among infants and toddlers, 2006 to 2015

“Among infants and toddlers, the proportion of ED visits for anaphylaxis per year increased from 20 per 100,000 visits to 50 per 100,000 visits (Ptrend <0.001). The rate of ED visits for anaphylaxis increased from 15 to 32 ED visits per 100,000 population of infants and toddlers (Ptrend <0.001).” (opens the source at this quote in a new tab)
“The proportion of hospitalization among anaphylaxis-related ED visits decreased from 19% to 6% (Ptrend <0.001).” (opens the source at this quote in a new tab)

United States emergency department visits and hospitalizations for anaphylaxis among adults aged 65 years and older, 2006 to 2014

“In 2006–2014, older adults experienced approximately 1,019,967 AAR-related ED visits; 173,844 AAR-related hospitalizations; 93,795 anaphylaxis-related ED visits; and 72,677 anaphylaxis-related hospitalizations.” (opens the source at this quote in a new tab)
“While AAR-related ED visit and hospitalization rates remained stable (P-trends=0.28 and 0.16, respectively), anaphylaxis-related ED visit and hospitalization rates significantly increased over time (37 visits per 100,000 population in 2006 to 51 in 2014, P-trend<0.001; 13 hospitalizations per 100,000 population in 2006 to 23 in 2014, P-trend<0.001), especially hospitalization rates for drug-related anaphylaxis (47 hospitalizations per 100,000 population in 2006 to 85 in 2014, P-trend<0.001).” (opens the source at this quote in a new tab)

Trend in United States pediatric emergency department visits for anaphylaxis, 2016 to 2022

“There were 42,909 ED visits for anaphylaxis with a 4.2% per year increase in visit incidence (95% CI 1.8, 6.7) during the study period.” (opens the source at this quote in a new tab)

State-level and health maintenance organization estimates of pediatric anaphylaxis rates in the United States

“A study observing emergency department visits and hospital admissions in the US State of Illinois due to anaphylaxis, estimated a 29.1% annual increase of emergency department and hospital admissions among children from 6.3 per 100,000 children in 2008 to 17.2 per 100,000 children in 2012” (opens the source at this quote in a new tab)
“These 2012 estimates are substantially higher than previous estimates of 10.5 per 100,000 person/year for all-cause anaphylaxis among pediatric patients treated from 1991-1997 by a large health maintenance organization in the state of Washington.” (opens the source at this quote in a new tab)

United Kingdom hospital admissions for food-induced anaphylaxis, 1998 to 2018

“Food anaphylaxis admissions increased from 1.23 to 4.04 per 100 000 population per year (from 1998 to 2018), an annual increase of 5.7% (95% confidence interval 5.5% to 5.9%, P<0.001).” (opens the source at this quote in a new tab)
“The largest increase in hospital admissions was observed in children younger than 15 years, with an increase from 2.1 to 9.2 admissions per 100 000 population per year (an annual increase of 6.6%, 95% confidence interval 6.3% to 7.0%).” (opens the source at this quote in a new tab)

Hospitalization incidence for food-induced anaphylaxis in Spain, 2016 to 2021

“A total of 2161 hospital admissions for FIA were recorded in Spain from 2016 to 2021. The overall incidence rate was 0.77 cases per 100,000 person-years. The highest incidence was found in those aged <15 years (3.68), with lower figures among those aged 15 to 59 years (0.25) and ≥60 years (0.29).” (opens the source at this quote in a new tab)